التفاصيل البيبلوغرافية
| العنوان: |
3D-printed smartphone-based device for fluorimetric diagnosis of ketosis by acetone-responsive dye marker and red emissive carbon dots. |
| المؤلفون: |
Yang, Fan, Yang, Linlin, Xu, Longchang, Guo, Wei, Pan, Lei, Zhang, Chuanglin, Xu, Shihao, Zhang, Ningning, Yang, Liang, Jiang, Changlong |
| المصدر: |
Microchimica Acta; Sep2021, Vol. 188 Issue 9, p1-10, 10p |
| مصطلحات موضوعية: |
ACETONE, ACETONEMIA, DIAGNOSIS, CONDENSATION reactions, SMARTPHONES, THREE-dimensional printing |
| مستخلص: |
A portable smartphone device is reported that uses 3D printing technology for the primary diagnosis of diseases by detecting acetone. The key part of the device consists of red carbon dots (RCDs), which are used as internal standards, and a sensing reagent (3-N,N-(diacethydrazide)-9-ethylcarbazole (2-HCA)) for acetone. With an excitation wavelength of 360 nm, the emission wavelengths of 2-HCA and RCDs are 443 nm and 619 nm, respectively. 2-HCA effectively captures acetone to form a nonfluorescent acylhydrazone via a condensation reaction occurring in aqueous solution, resulting in obvious color changes from blue-violet to dark red. The detection limit for acetone is 2.62 μM (~ 0.24 ppm). This is far lower than the ketone content in normal human blood (≤ 0.50 mM) and the acetone content in human respiratory gas (≤ 1.80 ppm). The device has good recovery rates for acetone detection in blood and exhaled breath, which are 90.56–109.98% (RSD ≤ 5.48) and 92.80–108.00% (RSD ≤ 5.07), respectively. The method designed here provides a reliable way to provide health warnings by visually detecting markers of ketosis/diabetes in blood or exhaled breath. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
