SGLT2 inhibition reduces myocardial oxygen consumption
| العنوان: | SGLT2 inhibition reduces myocardial oxygen consumption |
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| المؤلفون: | Søndergaard, Esben, Lauritzen, Esben S, Lauritsen, Katrine M, Åkerblom, Axel, 1977, Nuutila, Pirjo, Oldgren, Jonas, 1964, Gormsen, Lars C |
| المصدر: | Metabolism Open. 15 |
| مصطلحات موضوعية: | Meta-analysis, Myocardial external efficiency, Myocardial oxygen consumption, SGLT2 inhibitors, Type 2 diabetes |
| الوصف: | AIMS/HYPOTHESIS: SGLT2 inhibition is associated with a reduced risk of cardiac disease that is still largely unexplained. According to one hypothesis, improved myocardial energetics may explain the cardioprotective effects of SGLT2i. However, recent mechanistic studies that have addressed this question have lacked the power to detect discrete but still clinically significant effects.METHODS: We pooled data from two recent randomized clinical trials and performed a meta-analysis to determine the effect of SGLT2 inhibition on myocardial oxygen consumption and myocardial external efficiency measured by positron emission tomography.RESULTS: SGLT2 inhibition reduced myocardial oxygen consumption (-1.06 [95%CI: 0.22-1.89] mL/100 g/min (n = 59, p = 0.01)), but did not affect myocardial external efficiency (2.22 [95%CI: 0.66-5.11] % (n = 59, p = 0.13)).CONCLUSIONS: /interpretation: SGLT2 inhibition reduces myocardial oxygen consumption at rest, which may contribute to the drugs' cardioprotective effects. |
| وصف الملف: | electronic |
| الوصول الحر: | https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-490199Test https://doi.org/10.1016/j.metop.2022.100207Test https://uu.diva-portal.org/smash/get/diva2:1717107/FULLTEXT01.pdfTest |
| قاعدة البيانات: | SwePub |
| تدمد: | 25899368 |
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| DOI: | 10.1016/j.metop.2022.100207 |