دورية أكاديمية
Association of human leukocyte antigen DQ1 and dengue fever in a white Southern Brazilian population
| العنوان: | Association of human leukocyte antigen DQ1 and dengue fever in a white Southern Brazilian population |
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| المؤلفون: | José Roberto Polizel, Danilo Bueno, Jeane Eliete L Visentainer, Ana Maria Sell, Sueli Donizete Borelli, Luiza Tamie Tsuneto, Marcia Machado O Dalalio, Maria Teresa M Coimbra, Ricardo Alberto Moliterno |
| المصدر: | Memorias do Instituto Oswaldo Cruz, Vol 99, Iss 6, Pp 559-562 (2004) |
| بيانات النشر: | Fundação Oswaldo Cruz (FIOCRUZ), 2004. |
| سنة النشر: | 2004 |
| المجموعة: | LCC:Microbiology LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | human leukocyte antigens, dengue fever, Brazil, Microbiology, QR1-502, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Dengue is an infectious disease of viral etiology transmitted by the mosquitoes Aedes aegypti, A. albopictus, and A. scutellaris. It can develop either as a benign form or as a severe hemorrhagic form. Previous work showed an association of the hemorrhagic form with human leukocyte antigens (HLA), suggesting a role of genetic factors in disease susceptibility. Nevertheless, data on HLA association with the classical form of the disease is scarce in literature. Sixty-four patients and 667 normal individuals, living in the state of Paraná, Southern Brazil, were used as test and control group, respectively. The patients developed the disease during a virus 1 dengue outbreak either in Maringá city in 1995 (47) or in Paranavaí city in 1999 (17). The diagnostic was confirmed through serology and/or viral culture. HLA class I and II typing was performed by the classical microlynfocitotoxicity test using monoclonal antisera and fluorobeads. Qui-square statistical analysis confirmed a positive association with HLA-DQ1 (76.6% vs 57.7%; p = 0.005243; pc = 0.026215). HLA-DR1 also presented an increased frequency in the test group, not statistically significant after p correction though (32.8% vs 15.9%; p = 0.005729; pc = 0.080206). In conclusion, genetic factors may play a role on the susceptibility to the classical dengue, virus 1, in the Brazilian population. Further independent studies should be performed in the Brazilian population to confirm these preliminary data. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0074-0276 1678-8060 |
| العلاقة: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762004000600003Test; https://doaj.org/toc/0074-0276Test; https://doaj.org/toc/1678-8060Test |
| DOI: | 10.1590/S0074-02762004000600003 |
| الوصول الحر: | https://doaj.org/article/c82fe0b20b264e04af8055c39c6ca619Test |
| رقم الانضمام: | edsdoj.82fe0b20b264e04af8055c39c6ca619 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 00740276 16788060 |
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| DOI: | 10.1590/S0074-02762004000600003 |