دورية أكاديمية
NLRP3 polymorphism is associated with protection against human T-lymphotropic virus 1 infection
| العنوان: | NLRP3 polymorphism is associated with protection against human T-lymphotropic virus 1 infection |
|---|---|
| المؤلفون: | Anselmo Jiro Kamada, Alessandra Pontillo, Rafael Lima Guimarães, Paula Loureiro, Sergio Crovella, Lucas André Cavalcanti Brandão |
| المصدر: | Memorias do Instituto Oswaldo Cruz, Vol 109, Iss 7, Pp 960-963 (2014) |
| بيانات النشر: | Fundação Oswaldo Cruz (FIOCRUZ), 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Microbiology LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | NLRP3, NLRP1, single nucleotide polymorphisms, innate immunity, HTLV-1, Microbiology, QR1-502, Infectious and parasitic diseases, RC109-216 |
| الوصف: | Inter-individual heterogeneity in the response to human T-lymphotropic virus 1 (HTLV-1) infection has been partially attributed to host genetic background. The antiviral activity of the inflammasome cytoplasmic complex recognises viral molecular patterns and regulates immune responses via the activation of interleukin (IL)-1 family (IL-1, IL-18 and IL-33) members. The association between polymorphisms in the inflammasome receptors NLRP1 and NLRP3 and HTLV-1 infection was evaluated in a northeastern Brazilian population (84 HTLV-1 carriers and 155 healthy controls). NLRP3 rs10754558 G/G was associated with protection against HTLV-1 infection (p = 0.012; odds ratio = 0.37). rs10754558 affects NLRP3 mRNA stability; therefore, our results suggest that higher NLRP3 expression may augment first-line defences, leading to the effective protection against HTLV-1 infection. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1678-8060 0074-0276 |
| العلاقة: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000700960&lng=en&tlng=enTest; https://doaj.org/toc/1678-8060Test |
| DOI: | 10.1590/0074-0276140154 |
| الوصول الحر: | https://doaj.org/article/0706c980e41749978880624f78ab3c19Test |
| رقم الانضمام: | edsdoj.0706c980e41749978880624f78ab3c19 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16788060 00740276 |
|---|---|
| DOI: | 10.1590/0074-0276140154 |