Association Between Diabetic Macular Edema and Cardiovascular Events in Type 2 Diabetes Patients
| العنوان: | Association Between Diabetic Macular Edema and Cardiovascular Events in Type 2 Diabetes Patients |
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| المؤلفون: | Leveziel, Nicolas, Ragot, Stéphanie, Gand, Elise, Lichtwitz, Olivier, Halimi, Jean Michel, Gozlan, Julien, Gourdy, Pierre, Robert, Marie-Françoise, Dardari, Dured, Boissonnot, Michèle, Roussel, Ronan, Piguel, Xavier, Dupuy, Olivier, Torremocha, Florence, Saulnier, Pierre-Jean, Maréchaud, Richard, Hadjadj, Samy |
| المصدر: | Medicine |
| بيانات النشر: | Wolters Kluwer Health, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, endocrine system diseases, genetic structures, Myocardial Infarction, Observational Study, Risk Assessment, Amputation, Surgical, Macular Edema, Peripheral Arterial Disease, Risk Factors, Electroretinography, Odds Ratio, Humans, Aged, Glycated Hemoglobin, Diabetic Retinopathy, Middle Aged, eye diseases, Stroke, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Lower Extremity, Female, France, Research Article |
| الوصف: | Diabetic macular edema (DME) is the main cause of visual loss associated with diabetes but any association between DME and cardiovascular events is unclear. This study aims to describe the possible association between DME and cardiovascular events in a multicenter cross-sectional study of patients with type 2 diabetes. Two thousand eight hundred seven patients with type 2 diabetes were recruited from diabetes and nephrology clinical institutional centers participating in the DIAB 2 NEPHROGENE study focusing on diabetic complications. DME (presence/absence) and diabetic retinopathy (DR) classification were based on ophthalmological report and/or on 30° color retinal photographs. DR was defined as absent, nonproliferative (background, moderate, or severe) or proliferative. Cardiovascular events were stroke, myocardial infarction, and lower limb amputation. Details regarding associations between DME and cardiovascular events were evaluated. The study included 2807 patients with type 2 diabetes, of whom 355 (12.6%) had DME. DME was significantly and independently associated with patient age, known duration of diabetes, HbA1c, systolic blood pressure, and DR stage. Only the prior history of lower limb amputation was strongly associated with DME in univariate and multivariate analyses, whereas no association was found with regard to myocardial infarction or stroke. Moreover, both major (n = 32) and minor lower limb (n = 96) amputations were similarly associated with DME, with respective odds ratio of 3.7 (95% confidence interval [CI], 1.77–7.74; P = 0.0012) and of 4.29 (95% CI, 2.79–6.61; P |
| اللغة: | English |
| تدمد: | 1536-5964 0025-7974 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid________::d4892a5447d8dad19181d625eb90c30cTest http://europepmc.org/articles/PMC4616429Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid..........d4892a5447d8dad19181d625eb90c30c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15365964 00257974 |
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