A body shape index and vascular structure and function in Spanish adults (MARK study)
| العنوان: | A body shape index and vascular structure and function in Spanish adults (MARK study) |
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| المؤلفون: | Gomez-Marcos, Manuel A., Gomez-Sanchez, Leticia, Carmen Patino-Alonso, Maria, Recio-Rodriguez, Jose I., Gomez-Sanchez, Marta, Rigo, Fernando, Marti, Ruth, Agudo-Conde, Cristina, Ramos, Rafel, Rodriguez-Sanchez, Emiliano, Maderuelo-Fernandez, Jose A., Garcia-Ortiz, Luis, MARK Grp |
| المصدر: | Medicine |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, brachial ankle pulse wave velocity, área bajo la curva, Cross-sectional study, humanos, 030204 cardiovascular system & hematology, Carotid Intima-Media Thickness, a body shape index, 0302 clinical medicine, Risk Factors, análisis de regresión, intermediate cardiovascular risk, evaluación de riesgos, Area under curve, Medicine, Longitudinal Studies, 030212 general & internal medicine, mediana edad, ecografía, Ultrasonography, anciano, Anthropometry, Body Shape Index, General Medicine, Middle Aged, adulto, Cardiovascular Diseases, Area Under Curve, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Regression Analysis, Female, Research Article, Adult, European Continental Ancestry Group, enfermedades cardiovasculares, Observational Study, Pulse Wave Analysis, Risk Assessment, White People, 03 medical and health sciences, Humans, factores de riesgo, grosor de la íntima y media carotídea, Ankle Brachial Index, carotid intima media thickness, Vascular structure, cardio ankle vascular index, análisis de la onda del pulso, Aged, business.industry, Cross-Sectional Studies, antropometría, Multicenter study, Spain, estudios longitudinales, grupo de ascendencia continental europea, business, estudios transversales, índice tobillo-brazo, Demography |
| الوصف: | Supplemental Digital Content is available in the text A body shape index (ABSI) has been introduced as a marker of the relationship between body composition and all-cause mortality. However, until now, the relationships between ABSI and vascular structure and function have not been evaluated. The aim of this study was to investigate the association of ABSI with vascular structure and function in Spanish adults with intermediate cardiovascular risk. This cross-sectional study analyzed the data of 2354 subjects [age, 35–74 years (median, 62.0 years [range, 56.0–67.0 years]), 61.9% men] enrolled into the MediAte Risk management (MARK) study. ABSI was calculated by using the following formula: ABSI = waist circumference (m)/[body mass index2/3 × height (m)1/2)]. Vascular function was assessed by measuring cardio-ankle vascular index (CAVI) with the VaSera device and brachial ankle pulse wave velocity (baPWV) by using a validated equation. Vascular structure was assessed by measuring carotid intima-media thickness (IMT) by ultrasonography. Median value of ABSI was 0.083 (range, 0.081–0.090), mean CAVI was (8.5 ± 1.2), and median IMT was 0.727 (range, 0.672–0.799). The values of ABSI and CAVI were higher in men. After adjusting for confounders, ABSI was positively associated with CAVI, baPWV, and average mean IMT. Thus, for each unit increase in ABSI, CAVI increased by 0.16 units, baPWV by 0.25 m/s, and IMT by 0.033 mm. In the logistic regression analysis, the odds ratio of ABSI was > 1 for high CAVI ≥ 9, baPWV ≥ 15 m/s, and IMT ≥ 0.90 mm in the overall subject group, and in the sex- and age-specific (> 62 years, ≤ 62 years) subgroups, after adjusting for confounders. The area under the receiver-operating characteristic curve of the ABSI was 0.631 (95% confidence interval [CI], 0.608–0.654) for CAVI ≥ 9, and 0.617 (95% CI, 0.593–0.641) for high baPWV ≥ 15 m/s. ABSI showed a positive association with vascular structure and function, independent of other confounders that might influence weight and fat mass distribution in Spanish subjects at intermediate cardiovascular risk. Trial Registration: ClinicalTrials.gov Identifier: NCT01428934 (registered: September 2, 2011; last updated: September 8, 2016) |
| تدمد: | 1536-5964 0025-7974 0142-8934 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af323272ea6f8f05f8e78013f8312443Test https://doi.org/10.1097/md.0000000000013299Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....af323272ea6f8f05f8e78013f8312443 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15365964 00257974 01428934 |
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