Sex disparities in the effect of statins on lipid parameters
| العنوان: | Sex disparities in the effect of statins on lipid parameters |
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| المؤلفون: | Hunt, Nicholas B., Emmens, Johanna E., Irawati, Sylvi, de Vos, Stijn, Bos, Jens H.J., Wilffert, Bob, Hak, Eelko, de Boer, Rudolf A. |
| المصدر: | Medicine |
| بيانات النشر: | Lippincott Williams & Wilkins, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Adult, Male, medical record linkage, pharmacoepidemiology, Cholesterol, HDL, Observational Study, Cholesterol, LDL, Lipids, drug prescriptions, statins, Cohort Studies, Sex Factors, treatment outcome, sex, Humans, lipids (amino acids, peptides, and proteins), Female, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Research Article |
| الوصف: | Real-world evidence on a potential statin effect modification by sex is inconclusive, especially for the primary prevention of cardiovascular disease (CVD). We aimed to quantify the differences in the effect of statins on lipid parameters between men and women. The PharmLines Initiative linked the Lifelines Cohort Study and the IADB.nl prescription database. This database covers a representative population from the Netherlands. We selected participants aged ≥40 years at the index date: the date of the first prescription of any statin monotherapy in the study period 2006 to 2017. Multivariate regression modeling was used to compare the difference of the mean percentage change of lipid parameters (% mean difference [MD]) from baseline to follow-up measurement between the sexes. Out of 5366 statin users from approximately 50,000 participants available in the final linked database, 685 were statin initiators. At baseline, women had significantly higher levels of mean total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) than men (all P values |
| اللغة: | English |
| تدمد: | 1536-5964 0025-7974 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid________::f5f5c4850eb857f40dd880c9a7355d38Test http://europepmc.org/articles/PMC8758030Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid..........f5f5c4850eb857f40dd880c9a7355d38 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15365964 00257974 |
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