Acute myeloid leukemia in an 86-year-old man with AML1/ETO treated with Homoharringtonine and Arsenic Trioxide
| العنوان: | Acute myeloid leukemia in an 86-year-old man with AML1/ETO treated with Homoharringtonine and Arsenic Trioxide |
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| المؤلفون: | Yanhong Lu, Zhipeng He, Lili Chen, Meiling Chen, Yong Wu, Mengting Yang, Xueting Xiao, Yiping Huang, Huixian Wang, Jiaying Chen, Bixin Wang |
| المصدر: | Medicine |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Myeloid, Oncogene Proteins, Fusion, Antineoplastic Agents, Apoptosis, Disease, acute myeloid leukemia, 03 medical and health sciences, chemistry.chemical_compound, RUNX1 Translocation Partner 1 Protein, 0302 clinical medicine, Pharmacotherapy, Arsenic Trioxide, hemic and lymphatic diseases, medicine, Humans, Clinical Case Report, 030212 general & internal medicine, Arsenic trioxide, AML1/ETO, neoplasms, Aged, 80 and over, business.industry, Myeloid leukemia, Cell Differentiation, General Medicine, medicine.disease, Aml1 eto, Leukemia, Myeloid, Acute, Leukemia, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, Homoharringtonine, Core Binding Factor Alpha 2 Subunit, Cancer research, Drug Therapy, Combination, business, Research Article |
| الوصف: | Rationale: Acute myeloid leukemia (AML) is a malignantly clonal and highly heterogeneous disease. Although the treatment of AML has brought promising outcomes for younger patients, prognosis of the elderly remains dismal. Innovative regimens are increasingly necessary to be investigated. Patient concerns: We present an 86-year-old AML patient with fever, cough, and sputum production. Diagnoses: A diagnosis of AML with maturation (AML-M2) and AML1/ETO was made. Interventions: The patient was treated with a regimen of Homoharringtonine coupled with arsenic trioxide. Outcomes: The AML-M2 patient with AML1/ETO achieved incomplete remission, but showed few toxic side effects and improved survival. Besides, we analyzed the dynamic counts of complete blood cells during the treatment. The count of white blood cell had a positive correlation with the percentage of blast cells (r = 0.65), both of which had a negative correlation with the percentage of segmented neutrophils (r = –0.63, –0.89). Lessons: Homoharringtonine and arsenic trioxide may induce both the apoptosis and differentiation of leukemic cells in AML-M2 with AML1/ETO. |
| تدمد: | 1536-5964 0025-7974 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d586de5eda635cc6798396e2dc29a9Test https://doi.org/10.1097/md.0000000000014998Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....67d586de5eda635cc6798396e2dc29a9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15365964 00257974 |
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