Cerebral microbleeds in patients with ischemic cerebrovascular disease taking aspirin or clopidogrel
| العنوان: | Cerebral microbleeds in patients with ischemic cerebrovascular disease taking aspirin or clopidogrel |
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| المؤلفون: | Xuehui Ouyang, Lihong Ge, Junguo Liang, Haixia Yu, Qiong Wu, Hui Wu, Chao Ban |
| المصدر: | Medicine |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, China, medicine.medical_specialty, Myocardial Ischemia, MEDLINE, Observational Study, 03 medical and health sciences, 0302 clinical medicine, Leukoencephalopathies, Risk Factors, Internal medicine, Antithrombotic, Odds Ratio, medicine, Humans, cardiovascular diseases, 030212 general & internal medicine, Aged, Cerebral Hemorrhage, Retrospective Studies, enhanced T2∗-weighted magnetic resonance imaging, clopidogrel, Aspirin, business.industry, white matter hyperintensity, Retrospective cohort study, General Medicine, Odds ratio, Middle Aged, Clopidogrel, Hyperintensity, Diffusion Magnetic Resonance Imaging, 030220 oncology & carcinogenesis, Female, Observational study, cerebral microbleed, business, Platelet Aggregation Inhibitors, Research Article, medicine.drug |
| الوصف: | Cerebral microbleeds (CMBs) may be markers of intracerebral bleeding risk in patients receiving antithrombotic drugs. This study aimed to analyze CMBs and white matter hyperintensities (WMHs) in patients taking aspirin or clopidogrel. This retrospective study included patients with ischemic cardiovascular disease administered 75 mg/day aspirin (n = 150) or clopidogrel (n = 150, matched for age and gender) for >1 year (Affiliated Hospital of Inner Mongolia Medical University, China, from July, 2010 to July, 2015). Patients underwent T2-weighted imaging, T1-weighted imaging, diffusion-weighted imaging (DWI) and enhanced T2∗-weighted angiography (ESWAN) imaging (3.0-Tesla scanner). Baseline vascular risk factors for CMBs and macroscopic bleeding (MB) were evaluated using univariate and multivariate analyses. The aspirin and clopidogrel groups did not differ significantly in baseline characteristics or prevalences of CMBs or MB. The odds of MB were higher in patients with CMBs than in patients without CMBs in both the aspirin (odds ratio, 95% confidence interval: 4.09, 1.93–8.68; P 5 years showed elevated risk of CMBs in the aspirin (0.17; 0.09–0.36; P 1 year, and long-term use increased the risks of CMB and bleeding. |
| تدمد: | 1536-5964 0025-7974 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d13a013474fe1c142396dd656e3f9c4cTest https://doi.org/10.1097/md.0000000000014685Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d13a013474fe1c142396dd656e3f9c4c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15365964 00257974 |
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