التفاصيل البيبلوغرافية
| العنوان: |
Fusaric acid and derivatives as novel antimicrobial agents. |
| المؤلفون: |
Thanh, Tung Truong, Quoc, Thang Nguyen, Xuan, Huy Luong |
| المصدر: |
Medicinal Chemistry Research; Sep2020, Vol. 29 Issue 9, p1689-1696, 8p |
| مستخلص: |
The synthesis and screening of several fusaric acid (FA) and analogues against five common clinical pathogens (gram-positive and gram-negative) and in vitro hemolytic activity assay in human red blood cells, for the first time, were reported. The biological results reveal that FA and its analogues exhibited moderate antimicrobial activities. Compounds 2–5 and 7 showed growth inhibitory activity in gram-positive bacteria. Compounds 6 and 9 showed growth inhibitory activity in both gram-positive and gram-negative bacteria. None of the compounds induce hemolysis, which is potent for future drug development on this template. In addition, the structure–activity relationship and docking studies are discussed. [ABSTRACT FROM AUTHOR] |
|
Copyright of Medicinal Chemistry Research is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
