دورية أكاديمية
Extremely Low Activity of Serum Alanine Aminotransferase Is Associated with Long-Term Overall-Cause Mortality in the Elderly Patients Undergoing Percutaneous Coronary Intervention after Acute Coronary Syndrome
| العنوان: | Extremely Low Activity of Serum Alanine Aminotransferase Is Associated with Long-Term Overall-Cause Mortality in the Elderly Patients Undergoing Percutaneous Coronary Intervention after Acute Coronary Syndrome |
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| المؤلفون: | Doo Young Kim, Si-Woon Park, Hyung-Wook Han, Myeong-Kon Kim, Ha-Jung Kim |
| المصدر: | Medicina, Vol 59, Iss 2, p 415 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | acute coronary syndrome, alanine transaminase, frailty, mortality, percutaneous coronary intervention, Medicine (General), R5-920 |
| الوصف: | Background and Objectives: Recent studies revealed that the extremely low activity of serum alanine aminotransferase (ALT) is associated with frailty and contributes to increased mortality after acute physical stress. We aimed to investigate whether the extremely low activity of serum ALT (Materials and Methods: A retrospective medical record review was performed on 1597 patients diagnosed with ACS who underwent PCI at a single university hospital from February 2014 to March 2020. The associations between the extremely low activity of serum ALT and mortality were assessed using a stepwise Cox regression (forward: conditional). Results: A total of 210 elderly patients were analyzed in this study. The number of deaths was 64 (30.5%), the mean survival time was 25.0 ± 18.9 months, and the mean age was 76.9 ± 7.6 years. The mean door-to-PCI time was 74.0 ± 20.9 min. The results of stepwise Cox regression analysis showed that the extremely low activity of serum ALT (adjusted hazard ratio: 5.157, 95% confidence interval: 3.001–8.862, p < 0.001) was the independent risk factor for long-term overall-cause mortality in the elderly who underwent PCI after ACS diagnosis. Conclusions: The extremely low activity of serum ALT at ACS diagnosis is a significant risk factor for increased long-term overall-cause mortality in the elderly who underwent PCI after ACS diagnosis. It is noteworthy that a simple laboratory test at the time of diagnosis was found to be a significant risk factor for mortality. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 59020415 1648-9144 1010-660X |
| العلاقة: | https://www.mdpi.com/1648-9144/59/2/415Test; https://doaj.org/toc/1010-660XTest; https://doaj.org/toc/1648-9144Test |
| DOI: | 10.3390/medicina59020415 |
| الوصول الحر: | https://doaj.org/article/ba3f6ca552f444d883ea5b256754eee8Test |
| رقم الانضمام: | edsdoj.ba3f6ca552f444d883ea5b256754eee8 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 59020415 16489144 1010660X |
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| DOI: | 10.3390/medicina59020415 |