التفاصيل البيبلوغرافية
| العنوان: |
Capicua (CIC) mutations in gliomas in association with MAPK activation for exposing a potential therapeutic target. |
| المؤلفون: |
Darabi, Sourat, Xiu, Joanne, Samec, Timothy, Kesari, Santosh, Carrillo, Jose, Aulakh, Sonikpreet, Walsh, Kyle M., Sengupta, Soma, Sumrall, Ashley, Spetzler, David, Glantz, Michael, Demeure, Michael J. |
| المصدر: |
Medical Oncology; Jul2023, Vol. 40 Issue 7, p1-11, 11p |
| مستخلص: |
Gliomas are the most prevalent neurological cancer in the USA and care modalities are not able to effectively combat these aggressive malignancies. Identifying new, more effective treatments require a deep understanding of the complex genetic variations and relevant pathway associations behind these cancers. Drawing connections between gene mutations with a responsive genetic target can help drive therapy selections to enhance patient survival. We have performed extensive molecular profiling of the Capicua gene (CIC), a tumor and transcriptional suppressor gene, and its mutation prevalence in reference to MAPK activation within clinical glioma tissue. CIC mutations occur far more frequently in oligodendroglioma (52.1%) than in low-grade astrocytoma or glioblastoma. CIC-associated mutations were observed across all glioma subtypes, and MAPK-associated mutations were most prevalent in CIC wild-type tissue regardless of the glioma subtype. MAPK activation, however, was enhanced in CIC-mutated oligodendroglioma. The totality of our observations reported supports the use of CIC as a relevant genetic marker for MAPK activation. Identification of CIC mutations, or lack thereof, can assist in selecting, implementing, and developing MEK/MAPK-inhibitory trials to improve patient outcomes potentially. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
