Safe use of sorafenib in a patient undergoing salvage liver transplantation for recurrent hepatocellular carcinoma after hepatic resection
| العنوان: | Safe use of sorafenib in a patient undergoing salvage liver transplantation for recurrent hepatocellular carcinoma after hepatic resection |
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| المؤلفون: | Federico Aucejo, Richard D. Kim, Narayanan Menon |
| المصدر: | Medical Oncology. 28:1044-1047 |
| بيانات النشر: | Springer Science and Business Media LLC, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, Niacinamide, Sorafenib, Oncology, Cancer Research, medicine.medical_specialty, Carcinoma, Hepatocellular, Pyridines, medicine.medical_treatment, Antineoplastic Agents, Liver transplantation, urologic and male genital diseases, Internal medicine, medicine, Humans, heterocyclic compounds, Adverse effect, neoplasms, Neoadjuvant therapy, Salvage Therapy, Hematology, business.industry, Phenylurea Compounds, Benzenesulfonates, Liver Neoplasms, General Medicine, Middle Aged, medicine.disease, female genital diseases and pregnancy complications, digestive system diseases, Recurrent Hepatocellular Carcinoma, Liver Transplantation, Transplantation, Hepatocellular carcinoma, Neoplasm Recurrence, Local, business, medicine.drug |
| الوصف: | Sorafenib, a multikinase inhibitor targeting angiogenesis, cell survival, and proliferation in hepatocellular carcinoma (HCC) is a standard therapy for advanced stage disease. However, its utilization as neoadjuvant therapy is under investigation and remains an off label indication. The use of sorafenib in pre-liver transplant setting raises caveats associated with risk of bleeding, wound healing deficiencies, and hepatic decompensation. Herein, we report the case of a patient who after exhibiting HCC relapse post-hepatic resection underwent sorafenib therapy and subsequent transplantation. Sorafenib was well tolerated, and no adverse events were noticed. The use of sorafenib as neoadjuvant therapy in pre-transplant patients is feasible and deserves investigation in large clinical settings. |
| تدمد: | 1559-131X 1357-0560 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74994f618584e7c754dd02e372cb3a9eTest https://doi.org/10.1007/s12032-010-9625-xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....74994f618584e7c754dd02e372cb3a9e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1559131X 13570560 |
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