Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State

التفاصيل البيبلوغرافية
العنوان: Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State
المؤلفون: Zhang, Peng, Kwon, Alice L., Guzzo, Christina, Liu, Qingbo, Schmeisser, Hana, Miao, Huiyi, Lin, Yin, Cimbro, Raffaello, Huang, Jinghe, Connors, Mark, Schmidt, Stephen D., Dolan, Michael A., Armstrong, Anthony A., Lusso, Paolo
المصدر: mBio; March 2021, Vol. 12 Issue: 2
مستخلص: Elucidating the structure and function of the HIV-1 outer envelope proteins is critical for the design of an effective vaccine. Despite the availability of many high-resolution structures, key functional correlates in the envelope trimer remain undefined.
قاعدة البيانات: Supplemental Index
الوصف
تدمد:21612129
21507511
DOI:10.1128/mBio.00090-21