دورية
Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State
العنوان: | Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State |
---|---|
المؤلفون: | Zhang, Peng, Kwon, Alice L., Guzzo, Christina, Liu, Qingbo, Schmeisser, Hana, Miao, Huiyi, Lin, Yin, Cimbro, Raffaello, Huang, Jinghe, Connors, Mark, Schmidt, Stephen D., Dolan, Michael A., Armstrong, Anthony A., Lusso, Paolo |
المصدر: | mBio; March 2021, Vol. 12 Issue: 2 |
مستخلص: | Elucidating the structure and function of the HIV-1 outer envelope proteins is critical for the design of an effective vaccine. Despite the availability of many high-resolution structures, key functional correlates in the envelope trimer remain undefined. |
قاعدة البيانات: | Supplemental Index |
تدمد: | 21612129 21507511 |
---|---|
DOI: | 10.1128/mBio.00090-21 |