دورية أكاديمية
Gadolinium-chelate functionalized magnetic CuFeSe2 ternary nanocrystals for T1-T2 dual MRI and CT imaging in vitro and in vivo
| العنوان: | Gadolinium-chelate functionalized magnetic CuFeSe2 ternary nanocrystals for T1-T2 dual MRI and CT imaging in vitro and in vivo |
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| المؤلفون: | Lu-Yao Lai, Ying Jiang, Guang-Ping Su, Min Wu, Xiao-Fei Lu, Shao-Zhi Fu, Lu Yang, Jian Shu |
| المصدر: | Materials Research Express, Vol 8, Iss 4, p 045001 (2021) |
| بيانات النشر: | IOP Publishing, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Materials of engineering and construction. Mechanics of materials LCC:Chemical technology |
| مصطلحات موضوعية: | multimodal imaging, contrast agent, CuFeSe2, magnetic resonance imaging, x-ray computed tomography, Materials of engineering and construction. Mechanics of materials, TA401-492, Chemical technology, TP1-1185 |
| الوصف: | CuFeSe _2 nanomaterial with high thermal conversion efficiency, well superparamagnetism, effective x-ray attenuation ability, multifunctional groups and excellent biocompatibility is beneficial to the construction of multimodal imaging probes which can combine various imaging modes to provide a synergistic advantage over a single imaging mode. This study aimed to develop a novel multimodal nanocontrast agent CuFeSe _2 @diethylenetriaminepentaacetic acid (DTPA)-Gd to obtain imaging information with high specificity, high sensitivity and high contrast. The morphology and physical characteristics of CuFeSe _2 @DTPA-Gd were detected by transmission electron microscope, scanning electron microscope, x-ray single crystal diffraction, vibrating sample magnetometer and fourier transform infrared spectrometer. The toxicity of CuFeSe _2 @DTPA-Gd in vivo was evaluated by hematoxylin-eosin staining. The imaging capability of CuFeSe _2 @DTPA-Gd in vitro and in vivo was evaluated by magnetic resonance imaging (MRI) and computed tomography (CT). This study successfully prepared nanoparticles CuFeSe _2 @DTPA-Gd, and experimental results in this study demonstrated CuFeSe _2 @DTPA-Gd is expected to be a useful CT and MRI T1-weighted imaging/T2-weighted imaging three-modal contrast agent in clinic. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2053-1591 |
| العلاقة: | https://doaj.org/toc/2053-1591Test |
| DOI: | 10.1088/2053-1591/abf1a2 |
| الوصول الحر: | https://doaj.org/article/ede4a06639404b64a13f730453cbae2dTest |
| رقم الانضمام: | edsdoj.4a06639404b64a13f730453cbae2d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20531591 |
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| DOI: | 10.1088/2053-1591/abf1a2 |