Fish as Bioreactors: Transgene Expression of Human Coagulation Factor VII in Fish Embryos
| العنوان: | Fish as Bioreactors: Transgene Expression of Human Coagulation Factor VII in Fish Embryos |
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| المؤلفون: | K. John Pasi, Darren W. Williams, Geoffrey Goldspink, Paul J. Murdock, Norman Maclean, Ferenc Müller, M. Aziz. Rahman, Gyu-Lin Hwang, Hamid Farahmand |
| المصدر: | Marine Biotechnology. 6:485-492 |
| بيانات النشر: | Springer Science and Business Media LLC, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | DNA, Complementary, animal structures, food.ingredient, Microinjections, Zygote, Transgene, Genetic Vectors, Cytomegalovirus, Enzyme-Linked Immunosorbent Assay, Applied Microbiology and Biotechnology, Photometry, chemistry.chemical_compound, Bioreactors, Plasmid, food, Complementary DNA, Animals, Humans, Transgenes, Promoter Regions, Genetic, Blood Coagulation, Zebrafish, biology, Factor VII, Fishes, Embryo, Tilapia, biology.organism_classification, Molecular biology, chemistry, embryonic structures, Catfish |
| الوصف: | A plasmid containing human coagulation factor VII (hFVII) complementary DNA regulated by a cytomegalovirus promoter was microinjected into fertilized eggs of zebrafish, African catfish, and tilapia. The active form of hFVll was detected in the fish embryos by various assays. This positive expression of human therapeutic protein in fish embryos demonstrates the possibility of exploitation of transgenic fish as bioreactors. |
| تدمد: | 1436-2236 1436-2228 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59acb4bd743c97f81c4ba82b74b168daTest https://doi.org/10.1007/s10126-004-3121-2Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....59acb4bd743c97f81c4ba82b74b168da |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14362236 14362228 |
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