Heritability and coefficient of genetic variation analyses of phenotypic traits provide strong basis for high-resolution QTL mapping in the Collaborative Cross mouse genetic reference population
| العنوان: | Heritability and coefficient of genetic variation analyses of phenotypic traits provide strong basis for high-resolution QTL mapping in the Collaborative Cross mouse genetic reference population |
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| المؤلفون: | Richard Mott, Ervin I. Weiss, Yasser Salymah, Alexandra Dorman, Fuad A. Iraqi, Aysar Nashif, Ian Tomlinson, Hanifa Athamni, Ariel Shusterman, Yael Houri-Haddad, Morris Soller |
| المصدر: | Mammalian Genome. 25:109-119 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Genetics, Candidate gene, Genetic diversity, Quantitative Trait Loci, Inheritance Patterns, Chromosome Mapping, Genetic Variation, Mice, Inbred Strains, Genomics, Phenotypic trait, Heritability, Biology, Quantitative trait locus, Mice, Phenotype, Inbred strain, Models, Animal, Genetic variation, Animals |
| الوصف: | Most biological traits of human importance are complex in nature; their manifestation controlled by the cumulative effect of many genetic factors interacting with one another and with the individual's life history. Because of this, mouse genetic reference populations (GRPs) consisting of collections of inbred lines or recombinant inbred lines (RIL) derived from crosses between inbred lines are of particular value in analysis of complex traits, since massive amounts of data can be accumulated on the individual lines. However, existing mouse GRPs are derived from inbred lines that share a common history, resulting in limited genetic diversity, and reduced mapping precision due to long-range gametic disequilibrium. To overcome these limitations, the Collaborative Cross (CC) a genetically highly diverse collection of mouse RIL was established. The CC, now in advanced stages of development, will eventually consist of about 500 RIL derived from reciprocal crosses of eight divergent founder strains of mice, including three wild subspecies. Previous studies have shown that the CC indeed contains enormous diversity at the DNA level, that founder haplotypes are inherited in expected frequency, and that long-range gametic disequilibrium is not present. We here present data, primarily from our own laboratory, documenting extensive genetic variation among CC lines as expressed in broad-sense heritability (H2) and by the well-known "coefficient of genetic variation," demonstrating the ability of the CC resource to provide unprecedented mapping precision leading to identification of strong candidate genes. © 2014 Springer Science+Business Media. |
| تدمد: | 1432-1777 0938-8990 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c104f7be10e8463f32f198756b7fc9Test https://doi.org/10.1007/s00335-014-9503-5Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d2c104f7be10e8463f32f198756b7fc9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321777 09388990 |
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