مورد إلكتروني
Tumour necrosis factor allele variants and their association with the occurrence and severity of malaria in African children: a longitudinal study
| العنوان: | Tumour necrosis factor allele variants and their association with the occurrence and severity of malaria in African children: a longitudinal study |
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| المصدر: | ISSN: 1475-2875 |
| بيانات النشر: | 2015 |
| تفاصيل مُضافة: | Gichohi-Wainaina, W.N. Boonstra, A. Feskens, E.J.M. Demir, A.Y. Veenemans, J. Verhoef, H. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background Tumour necrosis factor (TNF) is central to the immune response to Plasmodium infection. Its plasma concentration is influenced by allele variants in the promoter region of TNF. The study’s objectives were to assess TNF allele variants (TNF-1031 , TNF-308 ): (1) modulation of malaria rates in young Tanzanian children; (2) modulation of the severity of malaria as indicated by haemoglobin concentrations at the time of presentation with febrile episodes; and (3) the association between Plasmodium infection and haemoglobin concentration in symptomless parasite carriers. Methods Data from a placebo-controlled trial in which 612 Tanzanian children aged 6–60 months with height-for-age z-score in the range -3 SD to 1.5 SD was utilised. Those with Plasmodium infection at baseline were treated with artemether-lumefantrine. An episode of malaria was predefined as current Plasmodium infection with an inflammatory response (axillary temperature =37.5°C or whole blood C-reactive protein concentration =8 mg/L) in children reported sick. Linkage disequilibrium (LD) pattern assessment as well as haplotype analysis was conducted using HAPLOVIEW. Cox regression models used in the primary analysis accounted for multiple episodes per child. Results Genotyping of 94.9% (581/612) children for TNF-1031 (TNF-1031 T>C); allele frequency was 0.39. Corresponding values for rs1800629 (TNF-308 G>A) were 95.4% (584/612) and 0.17. Compared to the wild type genotype (TT), malaria rates were increased in the TNF-1031 CC genotype (hazard ratio, HR [95% CI]: 1.41 [1.01¿1.97] and 1.31 [0.97¿1.76] for crude analysis and adjusting for pre-specified baseline factors, respectively) but decreased in those with the TNF-308 AA genotype (corresponding HR: 0.13 [0.02¿0.63] and 0.16 [0.04¿0.67]). These associations were weaker when analysing first episodes of malaria (P value -0.59 and 0.38, respectively). No evidence that allele variants of TNF-1031 and TNF-308 affected haemoglobin concentration at fi |
| مصطلحات الفهرس: | cerebral malaria, diabetes-mellitus, disease, gene, hla, linkage disequilibrium, plasmodium-falciparum malaria, polymorphisms, rheumatoid-arthritis, tnf-alpha promoter, info:eu-repo/semantics/article, Article/Letter to editor, info:eu-repo/semantics/publishedVersion |
| URL: | |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/4.0Test Wageningen University & Research |
| ملاحظة: | application/pdf Malaria Journal 14 (2015) ISSN: 1475-2875 ISSN: 1475-2875 English |
| أرقام أخرى: | NLWUP oai:library.wur.nl:wurpubs/489498 https://research.wur.nl/en/publications/tumour-necrosis-factor-allele-variants-and-their-association-withTest 10.1186/s12936-015-0767-3 1200330798 |
| المصدر المساهم: | WUR STAFF PUBNS From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1200330798 |
| قاعدة البيانات: | OAIster |
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