دورية أكاديمية
Effect of Paraoxon on the Oxidative Stress Indices and Lactate Dehydrogenase Activity in Rat Liver
| العنوان: | Effect of Paraoxon on the Oxidative Stress Indices and Lactate Dehydrogenase Activity in Rat Liver |
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| المؤلفون: | E Ghani, M Mohammadi, M Jafari, A Khoshbaten, AR Asgari |
| المصدر: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 14, Iss 1, Pp 45-52 (2012) |
| بيانات النشر: | Babol University of Medical Sciences, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Medicine LCC:Medicine (General) |
| مصطلحات موضوعية: | paraoxon, oxidative stress, liver, lactate dehydrogenase, rat, Medicine, Medicine (General), R5-920 |
| الوصف: | BACKGROUND AND OBJECTIVE: Paraoxon (active metabolite of parathion) is one of the most toxic organophosphate (OP) compounds. Acetyl cholinesterase inhibition is the main acute toxic mechanisms of OPs. Free radicals production and disruption of antioxidant defense systems is one of non-cholinergic effects of these compounds. In the present study, the effect of acute paraoxon administration on the oxidative stress indices in rat liver and lactate dehydrogenase (LDH) activity in plasma and liver were evaluated.METHODS: In the present study, 32 male Wistar rats (200-250 g) were randomly divided into 4 groups (6 animals in each group): control (corn oil as paraoxon solvent) and three experimental groups received different doses of paraoxon (0.07, 0.35, or 0.7 mg/kg body weight) intraperitoneally. Four hours after injection, under ether anesthesia, blood sample is given, liver tissue removed and transferred to liquid nitrogen. Superoxide dismutase (SOD), catalase (CAT), and LDH activities and the levels of glutathione (GSH) and malondialdehyde (MDA) were determined in liver tissue homogenates.FINDINGS: Significant increase in SOD activity and decrease in CAT activity at doses of 0.35 and 0.7 mg/kg of paraoxon were observed (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Persian |
| تدمد: | 1561-4107 2251-7170 |
| العلاقة: | http://jbums.org/article-1-3982-en.htmlTest; https://doaj.org/toc/1561-4107Test; https://doaj.org/toc/2251-7170Test |
| الوصول الحر: | https://doaj.org/article/1d4c5a6751d04d34accc20baa00f480cTest |
| رقم الانضمام: | edsdoj.1d4c5a6751d04d34accc20baa00f480c |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 15614107 22517170 |
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