Fluorine NMR studies of the human carbonic anhydrase–3,5‐difluorobenzenesulfonamide complex
| العنوان: | Fluorine NMR studies of the human carbonic anhydrase–3,5‐difluorobenzenesulfonamide complex |
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| المؤلفون: | D. L. Veenstra, John T. Gerig |
| المصدر: | Magnetic Resonance in Chemistry. 36 |
| بيانات النشر: | Wiley, 1998. |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | biology, Chemistry, Stereochemistry, Protein dynamics, chemistry.chemical_element, General Chemistry, Nuclear Overhauser effect, Fluorine-19 NMR, Ring (chemistry), Carbonic anhydrase, biology.protein, Fluorine, Organic chemistry, General Materials Science, Carbonic Anhydrase I, Carbonic anhydrase 3 |
| الوصف: | Fluorine and nitrogen-15 NMR experiments are described which show that 3,5-difluorobenzenesulfonamide binds to human carbonic anhydrase I in a 1:1 complex, that the bound inhibitor is present as an anion and that the aromatic ring of the inhibitor undergoes rapid rotation in the complex in spite of likely interactions with the aromatic ring of Phe-91 which are strong enough to give an appreciable 19F{1H} NOE. A previously predicted enhancement of binding by fluorination of the inhibitor was confirmed. © 1998 John Wiley & Sons, Ltd. |
| تدمد: | 1097-458X 0749-1581 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::1345eb3a19438caa14aedfa8dbcfc5a1Test https://doi.org/10.1002Test/(sici)1097-458x(199806)36:13 |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........1345eb3a19438caa14aedfa8dbcfc5a1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1097458X 07491581 |
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