Serum high-mobility group box 1 is correlated with interferon-α and may predict disease activity in patients with systemic lupus erythematosus
| العنوان: | Serum high-mobility group box 1 is correlated with interferon-α and may predict disease activity in patients with systemic lupus erythematosus |
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| المؤلفون: | Yonsu Son, Hideki Amuro, Noriko Inagaki-Katashiba, Akihiro Tanaka, Shosaku Nomura, Kayoko Kibata, Tohru Nishizawa, Tomoki Ito, Yoshio Ozaki |
| المصدر: | Lupus. 28:1120-1127 |
| بيانات النشر: | SAGE Publications, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Thrombomodulin, chemical and pharmacologic phenomena, HMGB1, Severity of Illness Index, Disease activity, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, immune system diseases, Interferon α, Humans, Lupus Erythematosus, Systemic, Medicine, In patient, HMGB1 Protein, skin and connective tissue diseases, Receptor, 030203 arthritis & rheumatology, biology, business.industry, Type I IFN production, Interferon-alpha, Middle Aged, Immune complex, 030104 developmental biology, High-mobility group, Case-Control Studies, Immunology, biology.protein, Cytokines, Female, business, Biomarkers |
| الوصف: | Sensing self-nucleic acids through toll-like receptors in plasmacytoid dendritic cells (pDCs), and the dysregulated type I IFN production, represent pathogenic events in the development of the autoimmune responses in systemic lupus erythematosus (SLE). Production of high-mobility group box-1 protein (HMGB1) promotes type I IFN response in pDCs. To better understand the active pathogenic mechanism of SLE, we measured serum levels of HMGB1, thrombomodulin, and cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-13, IL-17A, IL-17F, IFNα, IFNγ, TNFα) in 35 patients with SLE. Serum HMGB1 and IFNα were significantly higher in patients with active SLE (SLE Disease Activity Index (SLEDAI) score ≥ 6) compared with healthy donors or patients with inactive SLE. Furthermore, the HMGB1 levels were significantly correlated with IFNα levels. By qualitative analysis, the detection of serum IFNα or HMGB1 suggests active SLE and the presence of SLE-related arthritis, fever, and urinary abnormality out of SLEDAI manifestations. Collectively, HMGB1 and IFNα levels are biomarkers reflecting disease activity, and qualitative analysis of IFNα or HMGB1 is a useful screening test to estimate SLE severity and manifestations. Our results suggest the clinical significance of type I IFNs and HMGB1 as key molecules promoting the autoimmune process in SLE. |
| تدمد: | 1477-0962 0961-2033 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a513b8a6c92025ef5b917e48e0c1c49Test https://doi.org/10.1177/0961203319862865Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....0a513b8a6c92025ef5b917e48e0c1c49 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14770962 09612033 |
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