التفاصيل البيبلوغرافية
| العنوان: |
Quantification of change in vocal fold tissue stiffness relative to depth of artificial damage. |
| المؤلفون: |
Rohlfs, Anna-Katharina, Schmolke, Sebastian, Clauditz, Till, Hess, Markus, Müller, Frank, Püschel, Klaus, Roemer, Frank W., Schumacher, Udo, Goodyer, Eric |
| المصدر: |
Logopedics Phoniatrics Vocology; Oct2017, Vol. 42 Issue 3, p108-117, 10p |
| مصطلحات موضوعية: |
VOCAL cord physiology, BIOMECHANICS, COMPARATIVE studies, DEAD, ELASTICITY, LARYNX, PROBABILITY theory, STAINS & staining (Microscopy), T-test (Statistics), PRE-tests & post-tests, DATA analysis software, IN vivo studies |
| مستخلص: |
Objectives:To quantify changes in the biomechanical properties of human excised vocal folds with defined artificial damage. Methods:The linear skin rheometer (LSR) was used to obtain a series of rheological measurements of shear modulus from the surface of 30 human cadaver vocal folds. The tissue samples were initially measured in a native condition and then following varying intensities of thermal damage. Histological examination of each vocal fold was used to determine the depth of artificial alteration. The measured changes in stiffness were correlated with the depth of cell damage. Results:For vocal folds in a pre-damage state the shear modulus values ranged from 537 Pa to 1,651 Pa (female) and from 583 Pa to 1,193 Pa (male). With increasing depth of damage from the intermediate layer of the lamina propria (LP), tissue stiffness increased consistently (compared with native values) following application of thermal damage to the vocal folds. The measurement showed an increase of tissue stiffness when the depth of tissue damage was extending from the intermediate LP layer downwards. Conclusions:Changes in the elastic characteristics of human vocal fold tissue following damage at defined depths were demonstrated in anin vitroexperiment. In future, reproduciblein vivomeasurements of elastic vocal fold tissue alterations may enable phonosurgeons to infer the extent of subepithelial damage from changes in surface elasticity. [ABSTRACT FROM AUTHOR] |
|
Copyright of Logopedics Phoniatrics Vocology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
