Telomerase activity, telomere length and human telomerase reverse transcriptase expression in hepatocellular carcinoma is independent of hepatitis virus status
| العنوان: | Telomerase activity, telomere length and human telomerase reverse transcriptase expression in hepatocellular carcinoma is independent of hepatitis virus status |
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| المؤلفون: | Sanjeev Sharma, Nitin Saini, Anuradha Chakraborti, Radhika Srinivasan, Arvind Rajwanshi, Yogesh Chawla |
| المصدر: | Liver International. 29:1162-1170 |
| بيانات النشر: | Wiley, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, Hepatitis B virus, Telomerase, Carcinoma, Hepatocellular, Adolescent, Hepatitis C virus, Hepacivirus, Biology, medicine.disease_cause, Gene Expression Regulation, Enzymologic, Young Adult, Hepatitis Viruses, medicine, Humans, Telomerase reverse transcriptase, RNA, Messenger, Child, neoplasms, Aged, Neoplasm Staging, Aged, 80 and over, Hepatitis, Hepatology, Liver Neoplasms, Middle Aged, Telomere, Hepatitis B, medicine.disease, Molecular biology, digestive system diseases, Liver, Hepatocellular carcinoma, Female, psychological phenomena and processes |
| الوصف: | Background: Telomerase expression and the maintenance of a critical telomere length (TL) in cancer initiation indicates that telomere shortening and telomerase expression initiates cancer by induction of chromosomal instability. Methods: Telomerase activity, TL and human telomerase reverse transcriptase (hTERT) expression were investigated in 58 hepatocellular carcinoma (HCC) and 17 chronic hepatitis patients by the telomerase repeat amplification protocol, Southern blotting and reverse transcriptase-polymerase chain reaction. Results: Telomerase was positive in 76% of HCC and 11.8% of chronic hepatitis patients (P |
| تدمد: | 1478-3231 1478-3223 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1276ab18ac144be73c3b859bad940066Test https://doi.org/10.1111/j.1478-3231.2009.02082.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....1276ab18ac144be73c3b859bad940066 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14783231 14783223 |
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