Association between lipoproteins and telomere length in US adults: data from the NHANES 1999–2002
| العنوان: | Association between lipoproteins and telomere length in US adults: data from the NHANES 1999–2002 |
|---|---|
| المؤلفون: | Kai-Wen Zhou, Yun-Fen Chen, Gui-zhen Yang, Chi Chen |
| المصدر: | Lipids in Health and Disease, Vol 18, Iss 1, Pp 1-10 (2019) Lipids in Health and Disease |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Oncology, Adult, Male, medicine.medical_specialty, National Health and Nutrition Examination Survey, Endocrinology, Diabetes and Metabolism, Lipoproteins, Clinical Biochemistry, NHANES database, 030209 endocrinology & metabolism, Physical examination, Clinical nutrition, 030204 cardiovascular system & hematology, Demographic data, Correlation, Hyperlipoproteinemia Type II, Association, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Risk Factors, Internal medicine, medicine, Leukocytes, Humans, Lipoprotein, Nonlinearity, lcsh:RC620-627, Triglycerides, Aged, Telomere length, medicine.diagnostic_test, business.industry, Research, Biochemistry (medical), Cholesterol, HDL, Telomere Homeostasis, Cholesterol, LDL, Middle Aged, Telomere, Nutrition Surveys, Diet, lcsh:Nutritional diseases. Deficiency diseases, Female, business, Lipidology |
| الوصف: | Background Evidence regarding the correlation between lipoproteins and telomere length in US adults is limited. We aimed to investigate whether lipoproteins was associated with telomere length using US National Health and Nutrition Examination Survey (NHANES) database. Methods A total of 6468 selected participants were identified in the NHANES Data Base (1999–2002). The independent and dependent variables were lipoproteins and telomere length, respectively. The covariates included demographic data, dietary data, physical examination data, and comorbidities. Results In fully-adjusted model, we found that 0.1 differences of telomere length were positively associated with HDL-C [0.19 (95% CI 0.07, 0.31)], while the associations between LDL-C [0.19 (95% CI -0.27, 0.65)], TG [− 1.00 (95% CI -2.09, 0.07) and telomere length were not detected. By nonlinearity test, only the relationship between HDL-C and telomere length was nonlinear. The inflection point we got was 1.25. On the left side of the inflection point (telomere length ≤ 1.25), a difference in 0.1 of telomere length was associated with 0.50 difference in HDL-C. Conclusion After adjusting for demographic data, dietary data, physical examination data, and comorbidities, telomere length is not associated with LDL-C and TG, but is positively associated with HDL-C when telomere length is less than 1.25. Electronic supplementary material The online version of this article (10.1186/s12944-019-1030-7) contains supplementary material, which is available to authorized users. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ffd146b90e93f01069e57c3b16bf89Test http://link.springer.com/article/10.1186/s12944-019-1030-7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b0ffd146b90e93f01069e57c3b16bf89 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |