التفاصيل البيبلوغرافية
| العنوان: |
Thermotropic phase behavior of in vivo extracted human stratum corneum lipids. |
| المؤلفون: |
Bonté, Frédéric, Pinguet, Patrick, Saunois, Alex, Meybeck, Alain, Beugin, Sophie, Ollivon, Michel, Lesieur, Sylviane |
| المصدر: |
Lipids; Jun1997, Vol. 32 Issue 6, p653-660, 8p |
| مستخلص: |
The thermotropic phase behavior of lipids extracted either in vivo from inner forearm (SCLE) or plantar callus (PC) was investigated by differential scanning calorimetry and small angle X-ray diffraction. PC composition was chromatographically modified (MPC) by eliminating the more polar lipids in order to evaluate their role. Analysis of composition confirms the potential use of PC as a source of stratum corneum lipids. MPC and SCLE exhibit similar differential scanning calorimetry (DSC) profiles with a main transition around 50°C attributed to the solid-to-liquid phase transition of the ceramides. The absence of a transition around 50°C for PC suggests the possible perturbation of ceramide packing by the significantly high proportion of phospholipids. X-ray data suggest a high miscibility of sebum components in stratum corneum lipids with possible modification of chain packing. The MPC patterns show a lipid phase separation which underscores the role of polar lipids in cholesterol/free fatty acids/sterol esters/ceramides structural cohesion. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
