Increased Glyceride–Glycerol Synthesis in Liver and Brown Adipose Tissue of Rat: In-Vivo Contribution of Glycolysis and Glyceroneogenesis
| العنوان: | Increased Glyceride–Glycerol Synthesis in Liver and Brown Adipose Tissue of Rat: In-Vivo Contribution of Glycolysis and Glyceroneogenesis |
|---|---|
| المؤلفون: | Danúbia Frasson, Luiz Carlos Carvalho Navegantes, Renato Helios Migliorini, Valéria Ernestânia Chaves, Maria Antonieta Rissato Garófalo, Isis do Carmo Kettelhut |
| المصدر: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| بيانات النشر: | Wiley, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Glycerol, Male, medicine.medical_specialty, Clinical chemistry, Adipose Tissue, White, Glyceride, Adipose tissue, Biology, Biochemistry, Glycerides, chemistry.chemical_compound, Adipose Tissue, Brown, Internal medicine, Brown adipose tissue, medicine, Glyceroneogenesis, Animals, Glycolysis, Rats, Wistar, TECIDO ADIPOSO, Organic Chemistry, Fasting, Cell Biology, Rats, Endocrinology, medicine.anatomical_structure, Liver, chemistry, Glycerophosphates, Glycerol 3-phosphate, Phosphoenolpyruvate carboxykinase |
| الوصف: | We have previously shown that a high-protein, carbohydrate-free diet can decrease the production of glycerol-3-phosphate (G3P) from glucose and increase glyceroneogenesis in both brown (BAT) and epididymal (EAT) adipose tissue. Here, we utilized an in-vivo approach to examine the hypothesis that there is reciprocal regulation in the G3P synthesis from glucose (via glycolysis) and glyceroneogenesis in BAT, EAT and liver of fasted rats and cafeteria diet-fed rats. Glyceroneogenesis played a prominent role in the generation of G3P in the liver (~70 %) as well as in BAT and EAT (~80 %) in controls rats. The cafeteria diet induced an increase in the total glyceride-glycerol synthesis and G3P synthesis from glucose and a decrease in glyceroneogenesis in BAT; this diet did not affect either the total glyceride-glycerol synthesis or G3P generation from glyceroneogenesis or glycolysis in the liver or EAT. Fasting induced an increase in total glyceride-glycerol synthesis and glyceroneogenesis and a decrease in G3P synthesis from glucose in the liver but did not affect either the total glyceride-glycerol synthesis or G3P synthesis from glyceroneogenesis in BAT and EAT, despite a reduction in glycolysis in these tissues. These data demonstrate that reciprocal changes in the G3P generation from glucose and from glyceroneogenesis in the rat liver and BAT occur only when the synthesis of glycerides-glycerol is increased. Further, our data suggest that this increase may be essential for the systemic recycling of fatty acids by the liver from fasted rats and for the maintenance of the thermogenic capacity of BAT from cafeteria diet-fed rats. |
| تدمد: | 1558-9307 0024-4201 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4db41772423a608fa60eb0b36c46d07Test https://doi.org/10.1007/s11745-012-3683-0Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e4db41772423a608fa60eb0b36c46d07 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15589307 00244201 |
|---|