التفاصيل البيبلوغرافية
| العنوان: |
FKBP51 is involved in LPS-induced microglial activation via NF-κB signaling to mediate neuroinflammation. |
| المؤلفون: |
Gan, Yu-Ling1,2 (AUTHOR), Lin, Wan-Jung1,3 (AUTHOR), Fang, Ya-Ching1,3 (AUTHOR), Tang, Chih-Yung3 (AUTHOR), Lee, Yi-Hsuan1,2,4 (AUTHOR) yhlee3@nycu.edu.tw, Jeng, Chung-Jiuan1,4 (AUTHOR) cjjeng@nycu.edu.tw |
| المصدر: |
Life Sciences. Aug2024, Vol. 351, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*MICROGLIA, *NEUROINFLAMMATION, *ENCEPHALITIS, *GENE expression, *CENTRAL nervous system |
| مستخلص: |
FKBP5 encodes FKBP51, which has been implicated in stress-related psychiatric disorders, and its expression is often increased under chronic stress, contributing to mental dysfunctions. However, the precise role of FKBP51 in brain inflammation remains unclear. This study aimed to investigate the role of FKBP51 in microglia-mediated inflammatory responses in the central nervous system. We employed a peripheral lipopolysaccharide (LPS) administration model to compare microglial activation and cytokine gene expression between Fkbp5 knockout (Fkbp5 -KO) and wild-type (WT) male mice. Additionally, we used both BV2 and primary microglia in vitro to examine how Fkbp5 deletion influenced inflammation-related pathways and microglial functions. This study revealed that systemic LPS-induced microglial activation was significantly attenuated in Fkbp5 -KO mice compared with WT mice. In Fkbp5 -KO mice following the LPS challenge, there was a notable decrease in the expression of pro-inflammatory genes, coupled with an increase in the anti-inflammatory gene Arg1. Furthermore, Fkbp5 knockdown in BV2 microglial cells led to reduced expression of LPS-induced inflammatory markers, and targeted inhibition of NF-κB activation, while Akt signaling remained unaffected. Similar results were observed in Fkbp5 -KO primary microglia, which exhibited not only decreased microglial activation but also a significant reduction in phagocytic activity in response to LPS stimulation. This study highlights the critical role of FKBP51 in LPS-induced microglial activation and neuroinflammation. It shows that reducing FKBP51 levels attenuates inflammation through NF-κB signaling in microglia. This suggests that FKBP51 is a potential target for alleviating neuroinflammation-induced stress responses. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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