التفاصيل البيبلوغرافية
| العنوان: |
New Species Can Broaden Myelin Research: Suitability of Little Skate, Leucoraja erinacea. |
| المؤلفون: |
Möbius, Wiebke1,2 (AUTHOR) moebius@em.mpg.de, Hümmert, Sophie1 (AUTHOR) sophie.huemmert@stud.uni-goettingen.de, Ruhwedel, Torben1 (AUTHOR) ruhwedel@em.mpg.de, Kuzirian, Alan3 (AUTHOR) akuzirian@mbl.edu, Gould, Robert4 (AUTHOR) rmgould48@gmail.com, Sol-Foulon, Nathalie (AUTHOR) |
| المصدر: |
Life (2075-1729). Feb2021, Vol. 11 Issue 2, p136. 1p. |
| مصطلحات موضوعية: |
*MYELIN, *GENE regulatory networks, *NERVOUS system, *MYELIN proteins, *SCHWANN cells, *CELL communication, *OLIGODENDROGLIA |
| مستخلص: |
Although myelinated nervous systems are shared among 60,000 jawed vertebrates, studies aimed at understanding myelination have focused more and more on mice and zebrafish. To obtain a broader understanding of the myelination process, we examined the little skate, Leucoraja erinacea. The reasons behind initiating studies at this time include: the desire to study a species belonging to an out group of other jawed vertebrates; using a species with embryos accessible throughout development; the availability of genome sequences; and the likelihood that mammalian antibodies recognize homologs in the chosen species. We report that the morphological features of myelination in a skate hatchling, a stage that supports complex behavioral repertoires needed for survival, are highly similar in terms of: appearances of myelinating oligodendrocytes (CNS) and Schwann cells (PNS); the way their levels of myelination conform to axon caliber; and their identity in terms of nodal and paranodal specializations. These features provide a core for further studies to determine: axon–myelinating cell communication; the structures of the proteins and lipids upon which myelinated fibers are formed; the pathways used to transport these molecules to sites of myelin assembly and maintenance; and the gene regulatory networks that control their expressions. [ABSTRACT FROM AUTHOR] |
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