Emerging Treatment Options for Multi-Drug-Resistant Bacterial Infections
| العنوان: | Emerging Treatment Options for Multi-Drug-Resistant Bacterial Infections |
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| المؤلفون: | Maria Caterina Pace, Emanuele Durante-Mangoni, Roberto Andini, Roberto Giurazza, Pasquale Sansone, Maria Civita Mazza |
| المساهمون: | Giurazza, R., Mazza, M. C., Andini, R., Sansone, P., Pace, M. C., Durante-Mangoni, E. |
| المصدر: | Life Life, Vol 11, Iss 519, p 519 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Brand-new antibiotic, brand-new antibiotics, medicine.medical_specialty, medicine.drug_class, Science, 030106 microbiology, Ceftobiprole, Antibiotics, Review, resistance mechanisms, Plazomicin, General Biochemistry, Genetics and Molecular Biology, emerging infectious diseases, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Antibiotic resistance, Old revived antibiotic, Antimicrobial stewardship, Medicine, antimicrobial resistance, 030212 general & internal medicine, Intensive care medicine, Ecology, Evolution, Behavior and Systematics, extensively drug resistant, business.industry, place in therapy, Emerging infectious disease, Paleontology, Antimicrobial, Eravacycline, old revived antibiotics, drug therapy, chemistry, Space and Planetary Science, Tedizolid, business |
| الوصف: | Antimicrobial resistance (AMR) remains one of the top public health issues of global concern. Among the most important strategies for AMR control there is the correct and appropriate use of antibiotics, including those available for the treatment of AMR pathogens. In this article, after briefly reviewing the most important and clinically relevant multi-drug-resistant bacteria and their main resistance mechanisms, we describe the emerging antimicrobial options for both MDR Gram-positive cocci and Gram-negative bacilli, including recently marketed agents, molecules just approved or under evaluation and rediscovered older antibiotics that have regained importance due to their antimicrobial spectrum. Specifically, emerging options for Gram-positive cocci we reviewed include ceftaroline, ceftobiprole, tedizolid, dalbavancin, and fosfomycin. Emerging treatment options for Gram-negative bacilli we considered comprise ceftolozane-tazobactam, ceftazidime-avibactam, meropenem-vaborbactam, imipenem-relebactam, aztreonam-avibactam, minocycline, fosfomycin, eravacycline, plazomicin, and cefiderocol. An exciting scenario is opening today with the long awaited growing availability of novel molecules for the treatment of AMR bacteria. Knowledge of mechanisms of action and resistance patterns allows physicians to increasingly drive antimicrobial treatment towards a precision medicine approach. Strict adherence to antimicrobial stewardship practices will allow us to preserve the emerging antimicrobials for our future. |
| تدمد: | 2075-1729 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63d2f29b573795b6981a3a35b5fc0d51Test https://doi.org/10.3390/life11060519Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....63d2f29b573795b6981a3a35b5fc0d51 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20751729 |
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