Mutations of epigenetic regulators and of the spliceosome machinery in therapy-related myeloid neoplasms and in acute leukemias evolved from chronic myeloproliferative diseases.

التفاصيل البيبلوغرافية
العنوان:	Mutations of epigenetic regulators and of the spliceosome machinery in therapy-related myeloid neoplasms and in acute leukemias evolved from chronic myeloproliferative diseases.
المؤلفون:	Voso, M T, Fabiani, E, Fianchi, L, Falconi, G, Criscuolo, M, Santangelo, R, Chiusolo, P, Betti, S, D'Alo', F, Hohaus, S, De Stefano, V, Leone, G
المصدر:	Leukemia (08876924); Apr2013, Vol. 27 Issue 4, p982-985, 4p, 1 Diagram, 1 Chart
مصطلحات موضوعية:	LEUKEMIA genetics, GENETIC mutation, EPIGENETICS, SPLICEOSOMES, MYELOPROLIFERATIVE neoplasms, TUMORS
مستخلص:	This article discusses research on the prevalence of mutations of epigenetic regulators and of spliceosome enzymes as transforming events in therapy-related myeloid neoplasms (t-MN) compared with leukemias that evolved from chronic myeloproliferative neoplasms (MPN). Researchers learned that the highest frequency of mutations in acute leukemias evolved from MPN. They also revealed that the incidence of mutations varies in t-MN according to the type of previous malignancy.
قاعدة البيانات:	Complementary Index

الوصف
تدمد:	08876924
DOI:	10.1038/leu.2012.267