التفاصيل البيبلوغرافية
| العنوان: |
IL-10 is overexpressed in human cutaneous T-cell lymphoma and is required for maximal tumor growth in a mouse model. |
| المؤلفون: |
Wu, Xuesong1, Hsu, Daniel K.1, Wang, Kang-Hsin1, Huang, Yuanshen2, Mendoza, Lindsay1, Zhou, Youwen2, Hwang, Sam T.1 sthwang@ucdavis.edu |
| المصدر: |
Leukemia & Lymphoma. May2019, Vol. 60 Issue 5, p1244-1252. 9p. |
| مصطلحات موضوعية: |
*CUTANEOUS T-cell lymphoma, *TUMOR growth, *RECEPTOR antibodies, *SKIN diseases, *TUMOR microenvironment, *T cells |
| مستخلص: |
A crucial question pertains to a role of IL-10 as a tumorigenic factor, or just a marker of advanced disease in cutaneous T-cell lymphoma (CTCL). Herein, we measured significantly elevated IL-10 mRNA in a cohort of skin samples of patients with CTCL. Increased IL-10 was also detected in the tumor microenvironment of an established inflammation-dependent murine model of using MBL2 T lymphoma cells. Conditioned media from MBL2 cells was able to stimulate IL-10 production in bone marrow-derived macrophages in an IL-4-dependent manner. Implanted MBL2 T-cell lymphomas in IL-10KO mice were 50% smaller, accompanied by decreased numbers of infiltrating macrophages and reduced efficiency of M2-polarization compared with wild-type mice. With anti-IL-10R mAb treatment, both wild-type tumor-bearing mice and IL-10KO mice exhibited a further growth inhibition. Our data indicate that targeting IL-10 signaling with neutralizing antibodies to IL-10 or its receptor may have a great potential for advanced CTCL therapy. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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