Survivin-derived peptide epitopes and their role for induction of antitumor immunity in hematological malignancies
| العنوان: | Survivin-derived peptide epitopes and their role for induction of antitumor immunity in hematological malignancies |
|---|---|
| المؤلفون: | Mads Hald Andersen, Sandra Siegel, Birte Friedrichs, Norbert Schmitz, Matthias Zeis |
| المصدر: | Leukemia & Lymphoma. 47:978-985 |
| بيانات النشر: | Informa UK Limited, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | CD4-Positive T-Lymphocytes, Cancer Research, Apoptosis Inhibitor, Survivin, T-Lymphocytes, medicine.medical_treatment, CD8-Positive T-Lymphocytes, Biology, Cancer Vaccines, Epitope, Inhibitor of Apoptosis Proteins, Epitopes, Immune system, Antigen, Antigens, Neoplasm, medicine, Humans, Cancer, Hematology, Immunotherapy, medicine.disease, Tumor antigen, Neoplasm Proteins, Oncology, Hematologic Neoplasms, Immune System, Immunology, Cancer research, Peptides, Microtubule-Associated Proteins |
| الوصف: | The immune system's ability to detect and destroy tumor cells offers an attractive approach to broaden the spectrum of cancer therapies. Survivin, a member of the apoptosis inhibitor protein family, is a tumor antigen, overexpressed in human cancers giving rise to peptides eliciting spontaneous CD8+ and CD4+ responses. Due to its dual function, blockade of apoptosis and regulation of cell division, survivin is directly associated with tumor survival and therefore regarded as an ideal target structure for immunotherapeutic approaches. Strong evidence that survivin acts as a T-cell activating antigen has been collected in recent years and the first clinical trials using survivin-based vaccines aim to prove its therapeutic efficacy in the clinic. We focus on the role of survivin in hematological malignancies, including a list of survivin-derived peptides eliciting potent immune responses. |
| تدمد: | 1029-2403 1042-8194 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5ae467c59fcb41a3fd801666aece59Test https://doi.org/10.1080/10428190500464062Test |
| رقم الانضمام: | edsair.doi.dedup.....4d5ae467c59fcb41a3fd801666aece59 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10292403 10428194 |
|---|