Incidence, Presenting Features and Prognosis of Low-Grade B-Cell Non-Hodgkin's Lymphomas Population-Based Data from a Danish Lymphoma Registry
| العنوان: | Incidence, Presenting Features and Prognosis of Low-Grade B-Cell Non-Hodgkin's Lymphomas Population-Based Data from a Danish Lymphoma Registry |
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| المؤلفون: | L. S. Mortensen, Bjarne Egelund Christensen, Andersen E, F d'Amore, K. Thorling, A. M. Boesen, M. K. Jensen, M. Pedersen, Preben Johansen |
| المصدر: | Leukemia & Lymphoma. 12:69-77 |
| بيانات النشر: | Informa UK Limited, 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, medicine.medical_specialty, Pathology, Lymphoma, B-Cell, Adolescent, Denmark, Newly diagnosed, Gastroenterology, Danish, hemic and lymphatic diseases, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Humans, Medicine, Registries, Stage (cooking), Child, Cyclophosphamide, B cell, Aged, Demography, Neoplasm Staging, Hodgkin s, business.industry, Incidence, Incidence (epidemiology), Age Factors, Hematology, Middle Aged, Prognosis, medicine.disease, Survival Analysis, language.human_language, Lymphoma, Survival Rate, medicine.anatomical_structure, Oncology, Doxorubicin, Vincristine, Population based data, language, Prednisone, Chlorambucil, Female, business, Follow-Up Studies |
| الوصف: | During the period January 1983 to January 1988 1597 newly diagnosed cases of non-Hodgkin's lymphoma (NHL) were included in a Western Danish population-based NHL registry. Of these, 31% (N = 496) were low-grade NHL (LG-NHL) consisting of (Kiel): 9% lymphocytic (LY), 27% lymphoplasmacytic/-cytoid (IC), 53% follicular centroblastic/-centrocytic (CB/CCf) and 11% unclassifiable low-grade. LG-NHL (age range: 26-94 yrs, median: 64 yrs; M/F ratio: 0.8) had an age-standardised incidence rate (IR) of 2.7/10(5)/yr. Age-specific IR's showed an age-related exponential rise in all subtypes except for CB/CCf. Compared with the intermediate (IG)- and high-grade (HG) group, LG-NHL had more female cases (M/F ratio: 0.79 vs. 1.2; p = 0.0002), a higher frequency of stage III-IV disease (66% vs. 53%; p0.00005) and of bone marrow involvement (39% vs. 19%; p0.00005). A later revision of all IC cases (N = 132) distinguished 79 non-polymorphic (ICnp) from 25 polymorphic (ICp) cases; 28 cases were differently classified. In 34 LG-NHL patients histologic transformation was verified: CB/CCf to CB diffuse (22 pts) and LY to immunoblastic or CB type (6 pts). The 7-yr survival for LG-NHL was 63% (IG: 48%, HG: 38%; p0.00005). A Cox-regression analysis identified the following adverse prognostic factors for survival in LG-NHL: age50 with a relative risk (RR) of 3.2, hepatic involvement (RR = 2.1), elevated s-LDH (RR = 1.9), B-symptoms (RR = 1.8) and IC histology (ICnp+ICp) (RR = 1.7).(ABSTRACT TRUNCATED AT 250 WORDS) |
| تدمد: | 1029-2403 1042-8194 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ead76d00ac8733fea471cddd826be5bTest https://doi.org/10.3109/10428199309059573Test |
| رقم الانضمام: | edsair.doi.dedup.....6ead76d00ac8733fea471cddd826be5b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10292403 10428194 |
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