دورية أكاديمية
The effect of IL-1 receptor antagonist on the proliferation of hematopoietic progenitor cells in regenerating bone marrow
| العنوان: | The effect of IL-1 receptor antagonist on the proliferation of hematopoietic progenitor cells in regenerating bone marrow |
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| المؤلفون: | Jovcić, G, Ivanović, Z, Biljanović-Paunović, L, Bugarski, D, Stošić-Grujičić, Stanislava, Milenković, P |
| المصدر: | Leukemia |
| سنة النشر: | 1996 |
| المجموعة: | RADaR - Digital Repository of Archived Publications Institute for Biological Research "Sinisa Stankovic" / РАДаР - Репозиторијум Архивираних Дигиталних Радова Институт за биолошка истраживања "Синиша Станковић" |
| الوصف: | To evaluate the involvement of IL-1 on bone marrow granulocyte-macrophage (CFU-GM) and erythroid (BFU-E and CFU-E) progenitor cell regeneration during the recovery of hematopoiesis after sublethal irradiation of CBA mice, we examined the effects of IL-1 receptor blockade by recombinant human IL-1 receptor antagonist (rhIL-1ra). The actual number of progenitors and proportion of these cells in S phase of the cell cycle were determined in regenerating bone marrow cells obtained 3 days after 2 Gy irradiation both following the in vivo administration of rhIL-1ra, as well as after the in vitro preincubation with increasing amounts of rhIL-1ra. The results revealed that rhIL-1ra decreased the number and the proportion of CFU-GM in the S phase in regenerating bone marrow. As concerning erythroid progenitors, rhIL-1ra treatment suppressed BFU-E and enhanced CFU-E-derived colony growth, indicating that the biological effects of IL-1 might be different depending on the stage of differentiation. The observed effects pointed to the importance of the basal levels of IL-1, as well as IL-1 receptor expression during the recovery of hematopoiesis. ; null |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0887-6924 |
| العلاقة: | Rad_konverzija_3889; https://radar.ibiss.bg.ac.rs/handle/123456789/1894Test; https://hdl.handle.net/21.15107/rcub_ibiss_1894Test |
| الإتاحة: | https://radar.ibiss.bg.ac.rs/handle/123456789/1894Test https://hdl.handle.net/21.15107/rcub_ibiss_1894Test |
| حقوق: | restrictedAccess ; ARR |
| رقم الانضمام: | edsbas.1E0460CC |
| قاعدة البيانات: | BASE |
| تدمد: | 08876924 |
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