Proteasome inhibitors in the treatment of multiple myeloma
| العنوان: | Proteasome inhibitors in the treatment of multiple myeloma |
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| المؤلفون: | Jatin J. Shah, Robert Z. Orlowski |
| المصدر: | Leukemia. 23:1964-1979 |
| بيانات النشر: | Springer Science and Business Media LLC, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Oncology, Cancer Research, medicine.medical_specialty, Antineoplastic Agents, Article, Bortezomib, Lactones, chemistry.chemical_compound, Chemosensitization, hemic and lymphatic diseases, Internal medicine, medicine, Humans, Protease Inhibitors, Pyrroles, Multiple myeloma, Hematology, business.industry, medicine.disease, Boronic Acids, Carfilzomib, Proteasome, chemistry, Pyrazines, Immunology, Proteasome inhibitor, Multiple Myeloma, business, Oligopeptides, Salinosporamide A, medicine.drug |
| الوصف: | Targeting intracellular protein turnover by inhibiting the ubiquitin-proteasome pathway as a strategy for cancer therapy is a new addition to our chemotherapeutic armamentarium, and has seen its greatest successes against multiple myeloma. The first-in-class proteasome inhibitor bortezomib was initially approved for treatment of patients in the relapsed/refractory setting as a single agent, and was recently shown to induce even greater benefits as part of rationally-designed combinations that overcome chemoresistance. Modulation of proteasome function is also a rational approach to achieve chemosensitization to other anti-myeloma agents, and bortezomib has now been incorporated into the front-line setting. Bortezomib-based induction regimens are able to achieve higher overall response rates and response qualities than was the case with prior standards of care, and unlike these older approaches, maintain efficacy in patients with clinically- and molecularly-defined high-risk disease. Second-generation proteasome inhibitors with novel properties, such as NPI-0052 and carfilzomib, are entering the clinical arena, and showing evidence of anti-myeloma activity. In this spotlight review, we provide an overview of the current state of the art use of bortezomib and other proteasome inhibitors against multiple myeloma, and highlight areas for future study that will further optimize our ability to benefit patients with this disease. |
| تدمد: | 1476-5551 0887-6924 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70dbb635bcff79a2b7bb4d033728c302Test https://doi.org/10.1038/leu.2009.173Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....70dbb635bcff79a2b7bb4d033728c302 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765551 08876924 |
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