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ACE2 and TAS2R38 receptor expression in pediatric and adult patients in the nasal and oral cavity

التفاصيل البيبلوغرافية
العنوان: ACE2 and TAS2R38 receptor expression in pediatric and adult patients in the nasal and oral cavity
المؤلفون: Zechariah G. Franks, Kavitha Nandakumar, Lakshmi Santhanam, Laeben Lester, Jonathan M. Walsh, Nicholas M. Dalesio
المصدر: Laryngoscope Investigative Otolaryngology, Vol 9, Iss 1, Pp n/a-n/a (2024)
بيانات النشر: Wiley, 2024.
سنة النشر: 2024
المجموعة: LCC:Otorhinolaryngology
LCC:Surgery
مصطلحات موضوعية: ACE2, bitter taste receptor, coronavirus, COVID‐19, obesity, Otorhinolaryngology, RF1-547, Surgery, RD1-811
الوصف: Abstract Objective To investigate differences in angiotensin‐converting‐enzyme‐2 (ACE2) and bitter taste receptor (TAS2R38) expression between patient age groups and comorbidities to characterize the pathophysiology of coronavirus 19(COVID‐19) pandemic. ACE2 is the receptor implicated to facilitate SARS‐CoV‐2 infections and levels of expression may correlate to the severity of COVID‐19 infection. TAS2R38 has many non‐gustatory roles in disease, with some evidence of severe COVID‐19 disease in certain receptor phenotypes. Methods We conducted a prospective cohort study and collected nasal and lingual tissue from healthy pediatric (n = 22) and adult (n = 25) patients undergoing general anesthesia for elective procedures. RNA isolation and qPCR were performed with primers targeting ACE2 and TAS2R38. Results A total of 25 adult (52% male; 44% obese) and 22 pediatric (50% male; 36% obese) patients were enrolled, pediatric tissue had 43% more nasal ACE2 RNA expression than adults with a median fold change of 0.69 (IQR 0.37, 0.98) in adults and 0.99 (IQR 0.74, 1.43) in children (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2378-8038
العلاقة: https://doaj.org/toc/2378-8038Test
DOI: 10.1002/lio2.1207
الوصول الحر: https://doaj.org/article/21bd9c81a96f425592488d0f950acd9cTest
رقم الانضمام: edsdoj.21bd9c81a96f425592488d0f950acd9c
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23788038
DOI:10.1002/lio2.1207