Lipid-Dependent Interaction of Human N-BAR Domain Proteins with Sarcolemma Mono- and Bilayers
| العنوان: | Lipid-Dependent Interaction of Human N-BAR Domain Proteins with Sarcolemma Mono- and Bilayers |
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| المؤلفون: | Jochen Balbach, Andrea Auerswald, Annette Meister, Tobias Gruber |
| المصدر: | Langmuir. 36:8695-8704 |
| بيانات النشر: | American Chemical Society (ACS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Membranes, Sarcolemma, Chemistry, Lipid composition, Lipid Bilayers, Surfaces and Interfaces, Condensed Matter Physics, Membrane composition, law.invention, Domain (software engineering), Protein Domains, law, Electrochemistry, Biophysics, Pi, Humans, BAR domain, General Materials Science, Electron microscope, Spectroscopy, Biogenesis |
| الوصف: | The N-BAR domain of the human Bin1 protein is indispensable for T-tubule biogenesis in skeletal muscles. It binds to lipid mono- and bilayers that mimic the sarcolemma membrane composition, and it transforms vesicles into uniform tubules by generating a decorating protein scaffold. We found that Δ(1-33)BAR, lacking the N-terminal amphipathic helix (H0), and H0 alone bind to sarcolemma monolayers, although both proteins are not able to tubulate sarcolemma vesicles. By variation of the lipid composition, we elucidated the role of PI(4,5)P |
| تدمد: | 1520-5827 0743-7463 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38f97737f8dcc0bd29b4bf3969202677Test https://doi.org/10.1021/acs.langmuir.0c00649Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....38f97737f8dcc0bd29b4bf3969202677 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15205827 07437463 |
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