Effective Spatial Separation of PC12 and NIH3T3 Cells by the Microgrooved Surface of Biocompatible Polymer Substrates
| العنوان: | Effective Spatial Separation of PC12 and NIH3T3 Cells by the Microgrooved Surface of Biocompatible Polymer Substrates |
|---|---|
| المؤلفون: | Xiaoling Fu, Yingjun Wang, Hua Dong, Xiaodong Cao, Huichang Gao, Chuanbin Mao, Ye Zhu |
| المصدر: | Langmuir. 31:6797-6806 |
| بيانات النشر: | American Chemical Society (ACS), 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Biocompatible polymers, Polymers, Surface Properties, Cell, Biocompatible Materials, Model system, Cell Separation, macromolecular substances, PC12 Cells, Article, Mice, chemistry.chemical_compound, Polylactic Acid-Polyglycolic Acid Copolymer, Electrochemistry, medicine, Animals, General Materials Science, Lactic Acid, Spectroscopy, Cell Proliferation, Nerve reconstruction, Substrate (chemistry), Cell Differentiation, Surfaces and Interfaces, Condensed Matter Physics, Rats, PLGA, medicine.anatomical_structure, chemistry, NIH 3T3 Cells, Biophysics, Neural differentiation, Polyglycolic Acid |
| الوصف: | Most organs and tissues are composed of more than one type of cell that is spatially separated and located in different regions. This study used a microgrooved poly(lactic-co-glycolic acid) (PLGA) substrate to guide two types of cocultured cells to two spatially separated regions. Specifically, PC12 pheochromocytoma cells are guided to the inside of microgrooves, whereas NIH3T3 fibroblasts are guided to the ridge area in between neighboring parallel microgrooves. In addition, the microgrooved structures can significantly promote the proliferation and neural differentiation of PC12 cells as well as the osteogenic differentiation of NIH3T3 cells. Therefore, the microgrooved PLGA surface with separated PC12 and NIH3T3 cells can serve as a potential model system for studying nerve reconstruction in bone-repairing scaffolds. |
| تدمد: | 1520-5827 0743-7463 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fafb5afcbda34a85bb307150da076e6Test https://doi.org/10.1021/acs.langmuir.5b01018Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6fafb5afcbda34a85bb307150da076e6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15205827 07437463 |
|---|