التفاصيل البيبلوغرافية
| العنوان: |
Octreotide hardens the pancreas. |
| المؤلفون: |
Foitzik, T., Gock, M., Schramm, C., Prall, F., Klar, E. |
| المصدر: |
Langenbeck's Archives of Surgery; Apr2006, Vol. 391 Issue 2, p108-112, 5p, 2 Color Photographs, 1 Graph |
| مصطلحات موضوعية: |
PANCREATICODUODENECTOMY, SURGICAL complications, PANCREATIC surgery, OCTREOTIDE acetate, ANTINEOPLASTIC agents, GASTROINTESTINAL agents, OPERATIVE surgery |
| مستخلص: |
Background and aims: Leakage from pancreaticojejunostomy and development of pancreatic fistulas are the major postoperative complications in patients undergoing duodenopancreatectomy. The risk of developing these complications is higher when surgery is performed on a soft pancreas. A recent report suggests that octreotide hardens the pancreas when given intraoperatively. The present study aims at verifying this observation by measuring tissue hardness of the pancreas by a commercially available durometer in pigs with and without octreotide pretreatment. Methods: Three groups of pigs were investigated: Group 1 (n=6) received no treatment; group 2 (n=6) was treated with 3×100 μg octreotide for 1 day; group 3 (n=6) for 5 days. Thereafter, animals were killed and the pancreas was harvested for performing measurements: Tissue hardness was assessed by a commercially available durometer, and a suture holding test was performed using a Newton dynamometer. Results: There was a significant increase in tissue hardness between untreated control animals [26.3±2.5 S.U. (shore units)] and animals with 1 day octreotide pretreatment (29.8±2.6 S.U.; p=0.04) as well as between the groups treated for 1 and 5 days (34.8±2.8 S.U.; p=0.01). Suture holding capacity was higher in animals treated for 5 days. Conclusion: The present study agrees with a recent report suggesting that octreotide hardens the pancreas. Octreotide pretreatment may therefore be an advantage when performing surgery on a soft pancreas, i.e., in patients scheduled for duodenopancreatectomy for ampullary carcinomas or circumscript pancreatic tumors not associated with chronic pancreatitis. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
