التفاصيل البيبلوغرافية
| العنوان: |
Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial. |
| المؤلفون: |
Verweij, Jaap1 j.verweij@erasmusmc.nl, Casali, Paolo G.2, Zalcberg, John3, LeCesne, Axel4, Reichardt, Peter5, Blay, Jean-Yves6, Issels, Rolf7, Van Oosterom, Allan8, Hogendoorn, Pancras C. W.9, Van Glabbeke, Martine10, Bertulli, Rossella2, Judson, Ian11 |
| المصدر: |
Lancet. 9/25/2004, Vol. 364 Issue 9440, p1127-1134. 8p. |
| مصطلحات موضوعية: |
*IMATINIB, *GASTROINTESTINAL tumors, *TUMOR treatment, *MEDICAL research, *CLINICAL trials, *DRUG dosage |
| مستخلص: |
Background Imatinib is approved worldwide for use in gastrointestinal stromal tumors (GIST). We aimed to assess dose dependency of response and progression-free survival with imatinib for metastatic GIST. Methods 946 patients were randomly allocated imatinib 400 mg either once or twice a day. Those assigned the once a day regimen who had progression were offered the option of crossover. The primary endpoint was progression-free survival. Analysis was by intention to treat. Findings At median follow-up of 760 days (IQR 644-859), 263 (56%) of 473 patients allocated imatinib once a day had progressed compared with 235 (50%) of 473 who were assigned treatment twice a day (estimated hazard ratio 0.82 [95% CI 0.69-0.98]; p=0.026). Side-effects arose in 465/470 (99%) patients allocated the once daily regimen compared with 468/472 (99%) assigned treatment twice a day. By comparison with the group treated once a day, more dose reductions (77 [16%] vs 282 [60%]) and treatment interruptions (189 [40%] vs 302 [64%]) were recorded in patients allocated the twice daily regimen, but treatment in both arms was fairly well tolerated. 52 (5%) patients achieved a complete response, 442 (47%) a partial response, and 300 (32%) stable disease, with no difference between groups. Median time to best response was 107 days (IQR 58-172). Interpretation If response induction is the only aim of treatment, a daily dose of 400 mg of imatinib is sufficient; however, a dose of 400 mg twice a day achieves significantly longer progression-free survival. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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