التفاصيل البيبلوغرافية
| العنوان: |
Melanoma. |
| المؤلفون: |
Schadendorf, Dirk1,2 dirk.schadendorf@uk-essen.de, van Akkooi, Alexander C. J.3, Berking, Carola4, Griewank, Klaus G.1,2, Gutzmer, Ralf5, Hauschild, Axel6, Stang, Andreas7,8, Roesch, Alexander1,2, Ugurel, Selma1,2 |
| المصدر: |
Lancet. 9/15/2018, Vol. 392 Issue 10151, p971-984. 14p. |
| مصطلحات موضوعية: |
*SKIN cancer, *MELANOMA, *PRIMARY care, *CLINICAL trials, *PROGRAMMED cell death 1 receptors, *ANTINEOPLASTIC agents, *MELANOMA treatment, *CANCER treatment, *METASTASIS, *PROTEIN kinase inhibitors, *DEMOGRAPHY, *MEDICAL screening, *MEDLINE, *SUNSHINE, *SKIN tumors, *TUMOR classification, *ULTRAVIOLET radiation, *SYSTEMATIC reviews, *DISEASE incidence, *TUMOR treatment, *THERAPEUTICS |
| مستخلص: |
Cutaneous melanoma causes 55 500 deaths annually. The incidence and mortality rates of the disease differ widely across the globe depending on access to early detection and primary care. Once melanoma has spread, this type of cancer rapidly becomes life-threatening. For more than 40 years, few treatment options were available, and clinical trials during that time were all unsuccessful. Over the past 10 years, increased biological understanding and access to innovative therapeutic substances have transformed advanced melanoma into a new oncological model for treating solid cancers. Treatments that target B-Raf proto-oncogene serine/threonine-kinase (BRAF)V600 (Val600) mutations using selected BRAF inhibitors combined with mitogen-activated protein kinase inhibitors have significantly improved response and overall survival. Furthermore, advanced cutaneous melanoma has developed into a prototype for testing checkpoint-modulating agents, which has increased hope for long-term tumour containment and a potential cure. These expectations have been sustained by clinical success with targeted agents and antibodies that block programmed cell-death protein 1 in locoregional disease, which induces prolongation of relapse-free, distant-metastasis-free, and overall survival times. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
