التفاصيل البيبلوغرافية
| العنوان: |
성장호르몬 결핍 성인에서 체지방 변화 이상의 성장호르몬 치료 효과. (Korean) |
| العنوان البديل: |
Effects of Growth Hormone Treatment beyond the Body Fat Changes in GH-deficient Adults. (English) |
| المؤلفون: |
김경욱, 남수연, 김동선, 안철우, 김경래, 임승길, 이은직, 차봉수, 이현철, Bruun, Jens M., Richelsen, Bjørn |
| المصدر: |
Korean Journal of Obesity; Mar2013, Vol. 22 Issue 1, p56-65, 10p |
| مستخلص: |
Background: The mechanisms underlying the effects of growth hormone(GH) on fat metabolism in GH-deficient (GHD) patients are not fully understood. This study was to evaluate the effects of GH replacement before the body fat changes and their relevant parameters in GHD patients. Methods: In total, 14 (5 males and 9 females) GHD adults (mean 34.4 ± 8.2 yr, BMI 23.1 ± 1.0 kg/m2) received GH treatment for 12 weeks. Body composition by dual-energy X-ray absorptiometry and fasting serum analyses were assessed before and after treatment. Results: GH replacement did not affect body weight (60.9 ± 3.0, vs. 60.3 ± 3.3 kg, P = 0.30), body fat mass (19.7 ± 1.5, vs. 18.4 ± 1.8 kg, P = 0.10) or HOMA IR (1.65 ± 0.3, vs. 1.94 ± 0.4, P = 0.34). However, serum adiponectin and leptin levels were distinctly reduced after GH administration (6.86 ± 1.2, vs. 5.51 ± 0.8 mg/L, P = 0.03; 8.7 ± 1.1, vs. 6.5 ± 1.0 ng/mL, P < 0.01, respectively). Interestingly, correlations between body fat mass and adipokines were stronger (adiponectin, before r = -0.502, P = 0.07 vs. after r = -0.634, P = 0.02; leptin, before r = 0.378, P = 0.18 vs. after r = 0.711, P = 0.004) after GH administration. Conclusion: After 12 weeks-GH replacement, the reductions in serum adiponectin and leptin levels without significant body fat changes and the stronger correlations between body fat mass and these adipokines are reflective of the metabolic effects of GH probably due to the amelioration of compensatory mechanism of adiponectin like GHRH to overcome GH deficiency and leptin resistance in GHD patients. [ABSTRACT FROM AUTHOR] |
|
Copyright of Korean Journal of Obesity is the property of Korean Society for the Study of Obesity and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
