التفاصيل البيبلوغرافية
| العنوان: |
Classification of current anticancer immunotherapies. |
| المؤلفون: |
Galluzzi, Lorenzo, Vacchelli, Erika, Bravo-San Pedro, José-Manuel, Buqué, Aitziber, Senovilla, Laura, Baracco, Elisa Elena, Bloy, Norma, Castoldi, Francesca, Abastado, Jean-Pierre, Agostinis, Patrizia, Apte, Ron N, Aranda, Fernando, Ayyoub, Maha, Beckhove, Philipp, Blay, Jean-Yves, Bracci, Laura, Caignard, Anne, Castelli, Chiara, Cavallo, Federica, Celis, Estaban, Cerundolo, Vincenzo, Clayton, Aled, Colombo, Mario P, Coussens, Lisa, Dhodapkar, Madhav V, Eggermont, Alexander M, Fearon, Douglas T, Fridman, Wolf H, Fučíková, Jitka, Gabrilovich, Dmitry I, Galon, Jérôme, Garg, Abhishek, Ghiringhelli, François, Giaccone, Giuseppe, Gilboa, Eli, Gnjatic, Sacha, Hoos, Axel, Hosmalin, Anne, Jäger, Dirk, Kalinski, Pawel, Kärre, Klas, Kepp, Oliver, Kiessling, Rolf, Kirkwood, John M, Klein, Eva, Knuth, Alexander, Lewis, Claire E, Liblau, Roland, Lotze, Michael T, Lugli, Enrico, Mach, Jean-Pierre, Mattei, Fabrizio, Mavilio, Domenico, Melero, Ignacio, Melief, Cornelis J, Mittendorf, Elizabeth A, Moretta, Lorenzo, Odunsi, Adekunke, Okada, Hideho, Palucka, Anna Karolina, Peter, Marcus E, Pienta, Kenneth J, Porgador, Angel, Prendergast, George C, Rabinovich, Gabriel A, Restifo, Nicholas P, Rizvi, Naiyer, Sautès-Fridman, Catherine, Schreiber, Hans, Seliger, Barbara, Shiku, Hiroshi, Silva-Santos, Bruno, Smyth, Mark J, Speiser, Daniel E, Spisek, Radek, Srivastava, Pramod K, Talmadge, James E, Tartour, Eric, Van Der Burg, Sjoerd H, Van Den Eynde, Benoît J, Vile, Richard, Wagner, Hermann, Weber, Jeffrey S, Whiteside, Theresa L, Wolchok, Jedd D, Zitvogel, Laurence, Zou, Weiping, Kroemer, Guido |
| المصدر: |
Kimmel Cancer Center Faculty Papers |
| بيانات النشر: |
Jefferson Digital Commons |
| سنة النشر: |
2014 |
| المجموعة: |
Jefferson Digital Commons (Thomas Jefferson University, Philadelphia) |
| مصطلحات موضوعية: |
Department of Pathology, Anatomy and Cell Biology, Sidney Kimmel Medical College, Cell Biology, Signaling Program, Kimmel Cancer Center, Thomas Jefferson University, actinic keratosis, active immunization, acute granulocytic leukemia, adoptive cell transfer, antigen presenting cell, Article, basal cell carcinoma, breast carcinoma, cancer immunization, cancer immunotherapy, cell transfer, chronic lymphatic leukemia, chronic myeloid leukemia, colorectal carcinoma, condyloma acuminatum, dendritic cell, DNA immunization, drug efficacy, hairy cell leukemia, head and neck cancer, hematologic malignancy, hematopoietic stem cell transplantation, human |
| الوصف: |
During the past decades, anticancer immunotherapy has evolved from a promising therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now approved by the US Food and Drug Administration and the European Medicines Agency for use in cancer patients, and many others are being investigated as standalone therapeutic interventions or combined with conventional treatments in clinical studies. Immunotherapies may be subdivided into "passive" and "active" based on their ability to engage the host immune system against cancer. Since the anticancer activity of most passive immunotherapeutics (including tumor-targeting monoclonal antibodies) also relies on the host immune system, this classification does not properly reflect the complexity of the drug-host-tumor interaction. Alternatively, anticancer immunotherapeutics can be classified according to their antigen specificity. While some immunotherapies specifically target one (or a few) defined tumor-associated antigen(s), others operate in a relatively non-specific manner and boost natural or therapy-elicited anticancer immune responses of unknown and often broad specificity. Here, we propose a critical, integrated classification of anticancer immunotherapies and discuss the clinical relevance of these approaches. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
https://jdc.jefferson.edu/kimmelccfp/49Test; https://jdc.jefferson.edu/context/kimmelccfp/article/1048/viewcontent/Onco.pdfTest |
| الإتاحة: |
https://jdc.jefferson.edu/kimmelccfp/49Test
https://jdc.jefferson.edu/context/kimmelccfp/article/1048/viewcontent/Onco.pdfTest |
| رقم الانضمام: |
edsbas.76D0AF4A |
| قاعدة البيانات: |
BASE |
