Altered modulation of WNT-beta-catenin and PI3K/Akt pathways in IgA nephropathy
| العنوان: | Altered modulation of WNT-beta-catenin and PI3K/Akt pathways in IgA nephropathy |
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| المؤلفون: | Nicola Ancona, Diletta Domenica Torres, Francesco Paolo Schena, Sharon Cox, Gianluigi Zaza, Fabio Sallustio, Grazia Serino, Patrizia Stifanelli, Paola Pontrelli, Raffaella Verrienti, Francesco Pesce |
| المصدر: | Kidney international 78 (2010): 396–407. doi:10.1038/ki.2010.138 info:cnr-pdr/source/autori:Sharon N. Cox, Fabio Sallustio, Grazia Serino, Paola Pontrelli, Raffaella Verrienti, Francesco Pesce, Diletta D. Torres, Nicola Ancona, Patrizia Stifanelli, Gianluigi Zaza, Francesco P. Schena/titolo:Altered modulation of WNT-beta-catenin and PI3K%2FAkt pathways in IgA nephropathy/doi:10.1038%2Fki.2010.138/rivista:Kidney international/anno:2010/pagina_da:396/pagina_a:407/intervallo_pagine:396–407/volume:78 |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | lymphocytes, WNT beta catenin, Low protein, proliferation, Biology, urologic and male genital diseases, Peripheral blood mononuclear cell, Phosphatidylinositol 3-Kinases, Immunoglobulin A nephropathy, medicine, Leukocytes, PI3K/Akt, PTEN, Humans, Protein kinase B, PI3K/AKT/mTOR pathway, beta Catenin, Cell Proliferation, Gene Expression Profiling, Wnt signaling pathway, Glomerulonephritis, Glomerulonephritis, IGA, IgA nephropathy, medicine.disease, Microarray Analysis, Wnt Proteins, Nephrology, Catenin, Case-Control Studies, Immunology, biology.protein, gene expression, signaling, Proto-Oncogene Proteins c-akt, Signal Transduction |
| الوصف: | Immunoglobulin A nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide. The basic defect lies within the IgA immune system and in peripheral blood leukocytes, rather than local kidney abnormalities. To define the intracellular mechanisms leading to the disease, we conducted a microarray study to identify genes and pathways differentially modulated in peripheral blood leukocytes isolated from 12 IgAN patients and 8 healthy controls. The genes whose expression discriminated between the IgAN patients and controls were primarily involved in canonical WNT-beta-catenin and PI3K/Akt pathways. We also tested peripheral blood mononuclear cells and their subpopulations isolated from an independent group of IgAN patients and healthy controls. There were low protein levels of inversin and PTEN, key regulators of WNT-beta-catenin and PI3K/Akt, in IgAN patients, suggesting hyperactivation of these pathways. Also, there were increased phospho-Akt protein levels and nuclear beta-catenin accumulation with an enhanced peripheral blood mononuclear cell proliferation rate. Subpopulation analysis uncovered a major irregularity of WNT signaling in monocytes. Hence, hyperactivation of these pathways may provide insight into mechanisms contributing to the pathogenesis of IgAN. |
| تدمد: | 1523-1755 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097bdf3b1615039f87e1bb2bbfc3e6daTest https://pubmed.ncbi.nlm.nih.gov/20485333Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....097bdf3b1615039f87e1bb2bbfc3e6da |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15231755 |
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