Roles of SIRT3 in heart failure: from bench to bedside
| العنوان: | Roles of SIRT3 in heart failure: from bench to bedside |
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| المؤلفون: | Xianbao Liu, Wen-chao Song, Jian-an Wang, Dexing Hu |
| المصدر: | Journal of Zhejiang University-SCIENCE B. 17:821-830 |
| بيانات النشر: | Zhejiang University Press, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, SIRT3, Ischemia, Cardiomegaly, Myocardial Reperfusion Injury, Review, 030204 cardiovascular system & hematology, General Biochemistry, Genetics and Molecular Biology, Muscle hypertrophy, 03 medical and health sciences, 0302 clinical medicine, Sirtuin 3, Internal medicine, medicine, Animals, Humans, General Pharmacology, Toxicology and Pharmaceutics, Heart Failure, Pressure overload, General Veterinary, business.industry, General Medicine, medicine.disease, Bench to bedside, 030104 developmental biology, Heart failure, Cardiology, NAD+ kinase, Reactive Oxygen Species, business, Reperfusion injury |
| الوصف: | Heart failure (HF) represents the most common endpoint of most cardiovascular diseases (CVDs) which are the leading causes of death around the world. Despite the advances in treating CVDs, the prevalence of HF continues to increase. It is believed that better results of prognosis are obtained from prevention rather than additional treatment for HF. Therefore, it is reasonable to prevent the development of CVDs or other complications to HF. Most types of HF are attributed to contractile dysfunction, cardiac hypertrophy or remodeling, and ischemic injuries. SIRT3 is a mitochondrial nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase whose substrates vary from metabolic biogenesis-associated proteins to stress-responsive proteins. In recent years, a number of studies have highlighted the cardio-protective role of SIRT3 and, as such, efforts have been made to induce over-expression or increased activity of this protein. In this review, we provide an overview of the roles of SIRT3 in cardiac hypertrophy induced by pressure overload or agonists and cardiomyocytes ischemic injuries. Moreover, we will introduce the application of SIRT3 agonists in the prevention of cardiac hypertrophy and ischemia reperfusion injury. |
| تدمد: | 1862-1783 1673-1581 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c9d246df4469e47378df2f1eee3dfd8Test https://doi.org/10.1631/jzus.b1600253Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5c9d246df4469e47378df2f1eee3dfd8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18621783 16731581 |
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