Naturally Occurring Fragments from Two Distinct Regions of the Prostatic Acid Phosphatase Form Amyloidogenic Enhancers of HIV Infection
| العنوان: | Naturally Occurring Fragments from Two Distinct Regions of the Prostatic Acid Phosphatase Form Amyloidogenic Enhancers of HIV Infection |
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| المؤلفون: | Jacqueline Schnell, Wolf-Georg Forssmann, Ludger Ständker, Frank Kirchhoff, Christoph Meier, Nadia R. Roan, Onofrio Zirafi, Jan Münch, Franziska Arnold, Tanja Weil, Warner C. Greene, Christina M. Stürzel |
| المصدر: | Journal of Virology |
| بيانات النشر: | American Society for Microbiology, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, Amyloid, Acid Phosphatase, Amino Acid Motifs, Molecular Sequence Data, Immunology, Human immunodeficiency virus (HIV), Virus Attachment, HIV Infections, Semen, Peptide, Biology, medicine.disease_cause, Microbiology, Cell Line, Virology, medicine, Humans, Amino Acid Sequence, Vector (molecular biology), Enhancer, Hiv transmission, chemistry.chemical_classification, Molecular biology, Peptide Fragments, Virus-Cell Interactions, Biochemistry, Prostatic acid phosphatase, chemistry, Insect Science, HIV-1, Protein Tyrosine Phosphatases, Sequence Alignment |
| الوصف: | Semen is the major vector for HIV-1 transmission. We previously isolated C-proximal fragments of the prostatic acid phosphatase (PAP) from semen which formed amyloid fibrils that potently enhanced HIV infection. Here, we used the same methodology and identified another amyloidogenic peptide. Surprisingly, this peptide is derived from an N-proximal fragment of PAP (PAP85-120) and forms, similar to the C-proximal fragments, positively charged fibrillar structures that increase virion attachment to cells. Our results provide a first example for amyloid formation by fragments of distinct regions of the same precursor and further emphasize the possible importance of amyloidogenic peptides in HIV transmission. |
| وصف الملف: | application/pdf |
| تدمد: | 1098-5514 0022-538X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19678d65c604fe0862ef68899a15b6d1Test https://doi.org/10.1128/jvi.06121-11Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....19678d65c604fe0862ef68899a15b6d1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10985514 0022538X |
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