Evaluation of Isotonic Sodium Bicarbonate Solution for Alkalizing Effects in Conscious Calves
| العنوان: | Evaluation of Isotonic Sodium Bicarbonate Solution for Alkalizing Effects in Conscious Calves |
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| المؤلفون: | Izumi Abe, Shigehisa Tsumagari, Tsutomu Matsumoto, Shigehiro Iwabuchi, Ryuji Asano, Kazuyuki Suzuki |
| المصدر: | Journal of Veterinary Medical Science. 64:699-703 |
| بيانات النشر: | Japanese Society of Veterinary Science, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Cardiac output, Bicarbonate, Cattle Diseases, Blood Pressure, Random Allocation, chemistry.chemical_compound, Animal science, medicine, Animals, Respiratory function, Plasma Volume, Infusions, Intravenous, Acid-Base Equilibrium, Sodium bicarbonate, Dose-Response Relationship, Drug, General Veterinary, Metabolic acidosis, medicine.disease, Surgery, Sodium Bicarbonate, Treatment Outcome, Blood pressure, chemistry, Fluid Therapy, Cattle, Base excess, Isotonic Solutions, Acidosis |
| الوصف: | After intravenous (i.v.) infusion of various volumes of 1.35%-isotonic sodium bicarbonate solution (ISB), acid-base equilibrium, blood pressure, plasma volume and biochemical parameters in healthy Holstein calves were studied. Four calves each were randomly assigned to the low-dose (LD; i.v. infusion of 5 ml/kg ISB), middle-dose (MD; i.v. infusion of 10 ml/kg ISB) and the high-dose groups (HD; i.v. infusion of 15 ml/kg ISB). Administration volumes of ISB in the LD, MD and HD groups were decided based on the first half volumes of 5, 10 and 15 mEq of base requirement by the acceptable equation. Systemic, pulmonary artery and central venous pressures, cardiac output and plasma osmotic pressure were not changed by ISB infusion and remained constant throughout the experiment for all groups. There was good correlation (r(2) = 0.950) between relative changes in base excess and infused volume of bicarbonate (y=2.491x). The coefficient of distribution for bicarbonate ions was calculated to be 0.401 (=1/2.491). Therefore, it is suggested that a value of 0.4 would be most appropriate when calculating the base requirements in calves. Therefore, the first half volumes of ISB correcting base deficits of 5, 10 and 15 mEq in calves were estimated to be 6, 12 and 18 ml/kg, respectively. On the basis of the findings in this study, ISB may be used to correct metabolic acidosis without altering the plasma osmotic pressure, hemodynamic status and respiratory function in the calves. |
| تدمد: | 1347-7439 0916-7250 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ad59bb780f87e39325f16f711f79c6Test https://doi.org/10.1292/jvms.64.699Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....56ad59bb780f87e39325f16f711f79c6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13477439 09167250 |
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