التفاصيل البيبلوغرافية
| العنوان: |
Effect of Benazepril on Survival and Cardiac Events in Dogs with Asymptomatic Mitral Valve Disease: A Retrospective Study of 141 Cases. |
| المؤلفون: |
Pouchelon, J.-L., Jamet, N., Gouni, V., Tissier, R., Serres, F., Sampedrano Carlos, C., Castaignet, M., Lefebvre, H. P., Chetboul, V. |
| المصدر: |
Journal of Veterinary Internal Medicine; Jul2008, Vol. 22 Issue 4, p905-914, 10p, 5 Charts, 3 Graphs |
| مصطلحات موضوعية: |
ACE inhibitors, DOG diseases, MITRAL valve diseases, HEART diseases, ECHOCARDIOGRAPHY, MITRAL valve insufficiency |
| مستخلص: |
Background: Angiotensin-converting enzyme inhibitors (ACEIs) improve quality of life and extend the life span of dogs with naturally acquired ISACHC class II-III congestive heart failure (CHF). However, their effects on asymptomatic heart disease remain controversial. Hypothesis: Benazepril (BNZ), an ACEI, could have beneficial effects at the asymptomatic stage of degenerative mitral valve disease (MVD). Animals: Dogs with ISACHC class Ia MVD and moderate-to-severe mitral regurgitation (MR) assessed by the color Doppler mapping technique at entry (Day 0) were retrospectively included. Methods: Dogs were assigned to the treated group (BNZ group) if they received BNZ (and no other cardiac medication) from Day 0 or to the untreated group (UT group) if they did not receive any cardioactive treatment until occurrence of CHF. Results: A total of 141 dogs were included in the study, 66 in the BNZ group (dosage: 0.30 ± 0.13 mg/kg) and 75 in the UT group. In the population (n = 93) including all breeds except Cavalier (CKC) and King Charles Spaniels (KC), median survival time to all causes of death in the BNZ group (n = 34, 3.3 years) was significantly longer than in the UT group (n = 59, 1.9 years) as was time to cardiac event ( P < .05). Conversely, no effect of the BNZ treatment was observed in the CKC and KC population. Conclusions and Clinical Relevance: BNZ had beneficial effects in asymptomatic dogs other than CKC and KC affected by MVD with moderate-to-severe MR. Breed distribution should be taken into account for interpretation of clinical trials performed in dogs with cardiac disease. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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