دورية أكاديمية
أعرض في EDS

Immune reconstitution in HIV-1 infected patients treated for two years with highly active antiretroviral therapy

التفاصيل البيبلوغرافية
العنوان: Immune reconstitution in HIV-1 infected patients treated for two years with highly active antiretroviral therapy
المؤلفون: R. A. M. B. Almeida, L. R. Souza, S. A. Calvi, M. R. V. Ikoma, V. A. Silva, P. R. Curi, D. A. Meira
المصدر: Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 1, Pp 91-109 (2006)
بيانات النشر: SciELO
سنة النشر: 2006
المجموعة: Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية: HIV, immune reconstitution, antiretroviral, HAART, cytokines, CD45RA, CD45RO, Arctic medicine. Tropical medicine, RC955-962, Toxicology. Poisons, RA1190-1270, Zoology, QL1-991
الوصف: The aim of this paper was to evaluate the immune reconstitution of HIV-1 patients subjected to highly active antiretroviral therapy (HAART) for two years or more according to CD45RA and CD45RO cell count; determination of IL-2, IFN-gamma, IL-4, IL-10 and TNF-alpha serum levels; CD4+ T and CD8+ T lymphocyte count; and plasma viral load (VL) determination. For this purpose, a cross sectional study was carried out in the Tropical Diseases Area, Botucatu School of Medicine, São Paulo State University, UNESP, Botucatu, São Paulo, Brazil. Between June 2001 and April 2002, 37 HIV-1 infected patients were evaluated, 13 with treatment indication but untreated (G1), 9 subjected to HAART for 5-7 months (G2), and 15 treated for two years or more (G3); both treated groups used medication regularly and without failure. Forty-nine normal individuals were studied as controls (GC-1 and GC-2). There was a tendency (p<0.10) for the predominance of two nucleoside reverse transcriptase inhibitors (NRTI) associated with one non-nucleoside reverse transcriptase inhibitor (NNRTI) regimen in G2; and two NRTI associated with a protease inhibitor (PI) in G3. Statistical differences between groups were seen for CD45RA (G1<[G3=GC-2]; p<0.05) and CD45RO (G1[G2=G3]; p<0.001), TNF-alpha serum determination ([G1>G3; G2=intermediate]>GC-1; p<0.001), IL-2 (G1<[G2=G3=GC-1]; p<0.01), IFN-gamma ([G1=GC-1]<[GC-2=G3]; p<0.001), IL-4 and IL-10 ([G1=G2=G3]>GC-1; p<0.001), serum cytokine profiles, with a higher proportion of subtype 2 in G1 and mature subtype 0 in G2 and G3 (p<0.005). There was no statistical difference for CD8+ T lymphocyte counts (G1=G2=G3; p<0.50). Consistency was seen between positive correlations of profile 1 definer cytokines (IL-2 and IFN-gamma), CD45RA and CD45RO cells, and CD4+ T lymphocyte counts and between positive correlations of profile 2 definer cytokines ...
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1678-9199
العلاقة: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000100008Test; https://doaj.org/toc/1678-9199Test; https://doaj.org/article/79060125eaf4492c9ec9606b0fdedefcTest
DOI: 10.1590/S1678-91992006000100008
الإتاحة: https://doi.org/10.1590/S1678-91992006000100008Test
https://doaj.org/article/79060125eaf4492c9ec9606b0fdedefcTest
رقم الانضمام: edsbas.E79B8664
قاعدة البيانات: BASE
الوصف
تدمد:16789199
DOI:10.1590/S1678-91992006000100008