التفاصيل البيبلوغرافية
| العنوان: |
Effect of Multivitamin Supplementation on the Neurodevelopment of HIV-Exposed Tanzanian Infants: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. |
| المؤلفون: |
Manji, Karim P.1,2, McDonald, Christine M.2,3, Kupka, Roland4,5, Bosch, Ronald J.6, Kisenge, Rodrick1, Aboud, Said7, Bellinger, David C.8,9, Fawzi, Wafaie W.5,10,11, Duggan, Christopher P.3,5 |
| المصدر: |
Journal of Tropical Pediatrics. Aug2014, Vol. 60 Issue 4, p279-286. 8p. |
| مصطلحات موضوعية: |
*NEURAL development, *INFANT diseases, *HIV infections, *TANZANIANS, *MOTOR ability, *RANDOMIZED controlled trials, *PLACEBOS, *CLINICAL trials |
| مستخلص: |
Background: Micronutrient deficiencies and in utero exposure to HIV may impair infant neurodevelopment.Objective: To evaluate the effect of daily multivitamin supplementation on the cognitive, language and motor development of HIV-exposed Tanzanian infants.Methods: A total of 2387 infants were randomized to receive daily oral supplementation of multivitamins (B-complex, C and E) or placebo from age 6 weeks for 24 months. The cognitive, language and motor scales of the Bayley Scales of Infant and Toddler Development, third edition, were administered to a subset of 206 infants at age 15 months.Results: Multivitamin supplementation did not improve measures of cognitive development, expressive or receptive language or gross motor capabilities. There was a trend toward improved fine motor skills among infants randomized to the multivitamin group (difference in mean score = 0.38; 95% CI = −0.01, 0.78, p = 0.06).Conclusion: Daily provision of multivitamins to HIV-exposed infants does not substantially improve developmental outcomes at age 15 months. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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